Identification of MCM4 as a Prognostic Marker of Hepatocellular Carcinoma

Figure 2

MCM4 is high expression in hepatocellular carcinoma. (a–d) MCM4 was significantly upregulated in HCC from 360 HCC tissues and 49 normal tissue expression profile in TCGA (A), 49 pairs of HCC tissues and adjacent tissue expression profile in TCGA (b), GSE64041 data (c), and GSE 19665 data (d); (e) protein levels of MCM4 in normal tissue (left) and tumor tissue (right) by immunohistochemistry based on the Human Protein Atlas (liver normal tissue, patient ID 1846: female; 32 years old, hepatocyte staining intensity: weak; quantity: <25%; location: nuclear; liver cancer tissue, patient ID 983: female, 53 year, intensity: strong; quantity: >75%; location: nuclear); (f) the expression of MCM4 in 60 pairs of HCC and adjacent tissues from frozen specimens tested by real-time PCR; (g, h) the expression of MCM4 in 4 pairs of HCC and adjacent tissues from frozen specimens tested by western blot (g) and the statistical result of western blot (h). T: tumor; A: adjacent.

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