Single-Cell Transcriptomics-Based Study of Transcriptional Regulatory Features in the Mouse Brain Vasculature

Figure 3

Analysis of cell type-specific regulation in the mouse brain vasculature. (a–d) Fibroblasts: (a) rank for regulons in mouse brain vasculature cells based on regulon specificity scores; (b) endothelial cells are highlighted as red dots in the tSNE plot; (c) the expression values of the genes with the highest regulon activity scores are presented in the tSNE plot; (d) the SEEK analysis is used to find coexpression results of the top regulated genes in different GEO datasets. The -axis represents the different datasets, and the -axis represents the coexpression significance of the target gene in each dataset. Relevant datasets with significant correlation ( value < 0.05) are highlighted with yellow dots. (e–h) Same as (a–d) but for endothelial cells. (i–l) Same as (a–d) but for microglia. (m–p) Same as (a–d) but for oligodendrocytes.

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