Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population

Table 4

Allelic and genotypic frequency of NLRP3, COX-2, and IL-1β polymorphisms in Hashimoto’s thyroiditis (HT) and control groups.

Polymorphism	HT; ( (%))	Control; ( (%))	value	OR (95% CI)
IL-1β (rs1143634)
Codominant
CC	42 (31.1)	52 (35.9)	1	1
CT	80 (59.2)	66 (45.5)	0.131	1.5 (0.89-2.5)
TT	13 (9.7)	27 (18.6)	0.157	0.56 (0.25-1.24)
Dominant
CC	42 (31.1)	52 (35.9)	1	1
	93 (68.9)	93 (64.1)	0.423	1.2 (0.74-2)
Recessive
	123 (90.3)	125 (81.4)	1	1
TT	13 (9.7)	27 (18.6)	0.03	0.67 (0.21-0.91)
Overdominant
	53 (40.8)	79 (54.5)	1	1
CT	80 (59.2)	66 (45.5)	0.03	1.1 (0.76-1.8)
Allele
C	164 (60.7)	170 (58.6)	1	1
T	106 (39.3)	120 (41.4)	0.389	0.86 (0.6-1.2)
NLRP3 (rs3806265)
Codominant
TT	45 (33.3)	59 (40.7)	1	1
CT	61 (45.2)	59 (40.7)	0.279	1.3 (0.78 –2.2)
CC	29 (21.5)	27 (18.6)	0.325	1.4 (0.72-2.5)
Dominant
TT	45 (33.3)	59 (40.7)	1	1
	90 (66.7)	86 (59.3)	0.224	1.35 (0.83-2.2)
Recessive
	106 (78.5)	118 (81.4)	1	1
CC	29 (21.5)	27 (18.6)	0.568	1.2 (0.65-2.1)
Overdominant
	74 (54.8)	86 (59.3)	1	1
CT	61 (45.2)	59 (40.7)	0.466	1.2 (0.74-1.9)
Allele
T	151 (55.9)	177 (61)	1	1
C	119 (44.1)	113 (39)	0.26	1.2 (0.87-1.7)
COX-2 (rs2745557)
Codominant
GG	88 (65.2)	77 (53.1)	1	1
GA	36 (26.6)	59 (40.6)	0.017	0.53 (0.31-0.89)
AA	11 (8.2)	9 (6.3)	0.991	0.99 (0.38-2.5)
Dominant
GG	88 (65.2)	77 (53.1)	1	1
	47 (34.8)	68 (46.9)	0.035	0.56 (0.36-0.96)
Recessive
	124 (91.8)	136 (93.7)	1	1
AA	11 (8.2)	9 (6.3)	0.641	1.24 (0.49-3.1)
Overdominant
	99 (73.4)	66 (59.4)	1	1
GA	36 (26.6)	59 (40.6)	0.015	0.53 (0.31-0.89)
Allele
G	212 (78.5)	213 (73.5)	1	1
A	58 (21.5)	77 (26.5)	0.73	0.49 (0.31-0.88)