Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population

Table 5

Allelic and genotypic frequency of NLRP3, COX-2, and IL-1β polymorphisms in Graves’ disease (GD) and control groups.

Polymorphism	GD; ( (%))	Control; ( (%))	value	OR (95% CI)
IL-1β (rs1143634)
Codominant
CC	56 (44.8)	52 (35.9)	1	1
CT	62 (49.6)	66 (45.5)	0.601	0.87 (0.52-1.45)
TT	7 (5.6)	27 (18.6)	0.002	0.24 (0.097-0.6)
Dominant
CC	56 (44.8)	52 (35.9)	1	1
	68 (55.2)	93 (64.1)	0.136	0.69 (0.42-1.1)
Recessive
	118 (94.4)	125 (81.4)	1	1
TT	7 (5.6)	27 (18.6)	0.002	0.26 (0.11-0.6)
Overdominant
	63 (50.4)	79 (54.5)	1	1
CT	62 (49.6)	66 (45.5)	0.503	1.1 (0.72-1.9)
Allele
C	174 (69.6)	170 (58.6)	1	1
T	76 (30.4)	120 (41.4)	0.009	0.61 (0.43-0.88)
NLRP3 (rs3806265)
Codominant
TT	43 (34.4)	59 (40.7)	1	1
CT	46 (36.8)	59 (40.7)	0.81	1.07 (0.61 –1.83)
CC	36 (28.8)	27 (18.6)	0.062	1.8 (0.96-3.4)
Dominant
TT	43 (34.4)	59 (40.7)	1	1
	82 (65.6)	86 (59.3)	0.288	1.3 (0.8-2.1)
Recessive
	89 (71.2)	118 (81.4)	1	1
CC	36 (28.8)	27 (18.6)	0.05	1.7 (1-1.3)
Overdominant
	79 (63.2)	86 (59.3)	1	1
CT	46 (36.8)	59 (40.7)	0.513	0.85 (0.51-1.3)
Allele
T	132 (52.8)	177 (61)	1	1
C	118 (47.2)	113 (39)	0.055	1.4 (0.99-1.9)
COX-2 (rs2745557)
Codominant
GG	66 (52.8)	77 (53.1)	1	1
GA	47 (37.6)	59 (40.6)	0.776	0.92 (0.56-1.5)
AA	12 (9.6)	9 (6.3)	0.349	1.55 (0.61-3.5)
Dominant
GG	66 (52.8)	77 (53.1)	1	1
	59 (47.2)	68 (46.9)	0.96	1 (0.62-1.6)
Recessive
	113 (90.4)	136 (93.7)	1	1
AA	12 (9.6)	9 (6.3)	0.303	1.6 (0.65-3.9)
Overdominant
	78 (62.4)	86 (59.4)	1	1
GA	47 (37.6)	59 (40.6)	0.604	0.88 (0.53-1.4)
Allele
G	179 (71.6)	213 (73.5)	1	1
A	71 (28.4)	77 (26.5)	0.698	1 (0.75-1.6)