Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population

Table 6

Association of NLRP3, COX-2, and IL-1β SNPs with clinical and demographic characteristics of HT and GD groups.

HT group
				Genotypes
NLRP3 SNP	TT	CT	CC	CT vs. TT	CC vs. TT	CT vs. CC
Anti-TPO				0.169	0.402	0.011
IL-1β SNP	CC	CT	TT	CT vs. CC	TT vs. CC	CT vs. TT
Age of onset				0.311	0.311	0.011
GD group
				Genotypes
NLRP3 SNP	TT	CT	CC	CT vs. TT	CC vs. TT	CT vs. CC
FT4				0.088	0.001	0.148
FT3				0.087	0.001	0.209
COX-2 SNP	GG	GA	AA	GA vs. GG	AA vs. GG	GA vs. AA
TSH				0.019	0.901	0.106
IL-1β SNP	CC	CT	TT	CT vs. CC	TT vs. CC	CT vs. TT
TSH				0.321	0.008	0.045