Protective Effect and Mechanism of Bone Morphogenetic Protein-4 on Apoptosis of Human Lens Epithelium Cells under Oxidative Stress

<div>Hoechst staining of cells. Images (a–c) show alterations in the nuclear morphology after H<sub>2</sub>O<sub>2</sub> and H<sub>2</sub>O<sub>2</sub>+BMP-4 treatment of HLE-B3 cells. Arrows indicate the alterations in nuclear morphology. Normal cell nuclei were stained lightly and uniformly. Under oxidative stress, the nuclei were fragmented and stained with dense hyperchromatism. After BMP-4 treatment, the nucleus fragmentation was obviously improved. (d) Quantification of fragmented nuclear number. 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Figure 3

Figure 3: Protective Effect and Mechanism of Bone Morphogenetic Protein-4 on Apoptosis of Human Lens Epithelium Cells under Oxidative Stress 