Studies on the Role of circRNAs in Osteoarthritis

Table 1

Articles about the correlation between circRNAs and OA in the recent 5 years.

	circRNA ID	Gene symbol	Regulation	miRNAs	Target gene/pathway	Reference	Year
1	hsa_circ_0141827	SERPINE2	Down	miR-1271	ERG pathway, SOX, COL2	Shen et al. [7]	2019
2	hsa_circ_0092516	NT5C2	Down	miR-337-3p	MMP-1, COL2	Huang et al. [8]	2020
3	hsa_circ_0020014	DUSP5	NA	NA	NA	Wang et al. [9]	2020
4	hsa_circ_0041552	UBE2G1	Down	miR-373	HIF-1a	Chen et al. [10]	2020
5	hsa_circ_0000448	GCN1L1	Down	miR-330-3p	TNF-α, ADAMTS4	Zhu et al. [11]	2020
6	hsa_circ_0021592	HIPK3	Down	miR-124	SOX-8	Wu et al. [12]	2020
7	hsa_circ_0129854	VCAN	NA	NA	NF-κB pathway	Ma et al. [13]	2020
8	hsa_circ_0080978	CDK14	Down	miR-125a-5p	SOX-9, Smad-2	Shen et al. [14]	2020
9	hsa_circ_0136474	ASH2L	Down	miR-127-5p	MMP-13	Li et al. [15]	2019
10	hsa_circ_0129214	PDE4D	Down	miR-103a-3p	FGF18	Wu et al. [16]	2021
11	hsa_circ_0055722	ANKRD36	Down	miR-599	Casz1	Zhou et al. [17]	2021
12	hsa_circ_0005105	SEC24A	Down	miR-26a	NAMPT	Wu et al. [18]	2017
13	hsa_circ_0032131	PRKCH	Down	miR-1182	NA	Wang et al. [19, 20]	2019
14	hsa_circ_0026176	TMBIM6	Down	miR-27a	MMP-13	Bai et al. [21]	2020
15	hsa_circ_9119^#	NA	Down	miR-26a	PTEN	Chen et al. [22]	2020
16	hsa_circ_0025119; hsa_circ_0025113; hsa_circ_0009897; hsa_circ_0002447	VWF; VWF; PLOD1; COL6A3	NA	NA	NA	Wang et al. [23]	2020
17	hsa_circ_7^#	NA	Down	miR-7	PI3K/AKT/mTOR	Zhou et al. [24, 25]	2020
18	hsa_circ_0045714; hsa_circ_0002485; hsa_circ_0005567	UNK; ATP9B; EPS15	NA	NA	NA	Xiao et al. [26]	2019
19	NA^#	PSM3	Down	miR-296-5p		Ni et al. [27]	2020
20	hsa_circ_100226^#	MSR	Down	miR-875	TNF-α	Liu et al. [28]	2017
21	hsa_circ_0001946	CDR1	Down	miR-641	COL2, IL-6	Zhang et al. [29]	2020
22	hsa_circ_0040639	CDH13	Down	miR-296-3p	PTEN	Zhou et al. [30]	2020
23	hsa_circ_0023404	RNF121	Down	miR-665	MYD88	Wang et al. [31]	2020
24	hsa_circ_0141827	SERPINE2	Down	miR-495	TGFBR2	Zhang et al. [32]	2020
25	hsa_circ_0035826	CSNK1G1	Down	miR-4428	FUT2	Xiao et al. [33]	2020
26	hsa_circ_0005567	EPS15	Down	miR-495	ATG14	Zhang et al. [34]	2020
27	hsa_circ_0010014	DHRS3	Down	miR-183-5p	GREM1	Jiang et al. [35]	2020
28	hsa_circ_0072655	ADAMTS6	Down	miR-431-5p	IL-β	Fu et al. [36]	2020
29	hsa_circ_0045714	UNK	Down	miR-193b	IGF1R	Li et al. [37]	2017
30	hsa_circ_0114876	PTPRA	Down	miR-671	TRAF2	Wang et al. [38]	2021
31	hsa_circ_0104873; hsa_circ_0104595; hsa_circ_0101251	IQGAP1; SCAPER; RP11-909M7.3	NA	NA	NA	Yu et al. [39]	2018
32	hsa_circ_0017855	RSU1	Down	miR-93-5p	MAP3K8	Yang et al. [40]	2021
33	hsa_circ_0045714	UNK	Down	miR-218-5p	HRAS	Jiang et al. [41]	2021

Note: “NA” means not available, and “#” means no relevant information in circBase.