ZC3H15 Correlates with a Poor Prognosis and Tumor Progression in Melanoma

<div>ZC3H15 is required for colony formation and tumorigenesis of melanoma cells. (a) Colony formation assay was carried out in A375 and MV3 cells after ZC3H15-knockdown and ZC3H15 restoration. (b) The growth curve of xenograft tumors was analyzed, and <svg height="8.68572pt" id="M34" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g></svg> value is indicated. (c) The size and weight of xenograft tumors were analyzed. (d) Immunohistochemical staining was performed to detect the expression of ZC3H15 and Ki67 in ZC3H15-knockdown and ZC3H15 restoration tumor tissues. 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BioMed Research International

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Figure 5

Figure 5: ZC3H15 Correlates with a Poor Prognosis and Tumor Progression in Melanoma 