ADAM17 Mediates Hypoxia-Induced Keratinocyte Migration via the p38/MAPK Pathway

<div>Hypoxia promoted keratinocyte migration. (a) HaCaT cells were subjected to scratch wounding with a micropipette tip (200 <i>μ</i>l) and then incubated under normoxic condition (21% O<sub>2</sub>) or hypoxic condition (1% O<sub>2</sub>) (0, 6, 12, and 24 hours). The cells were recorded by time-lapse video microscopy at different times. (b) Quantification analysis of wound healing assays using ImageJ software. (c) HaCaT cell proliferation was determined using a Cell Counting Kit-8 assay. (d) The effect of hypoxic (1% O<sub>2</sub>) treatment on cell motility trajectories in HaCaT cells, filmed for 12 hours using time-lapse video microscopy. (e) The statistical value of cell trajectory speed. 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BioMed Research International

fig1

Figure 1

Figure 1: ADAM17 Mediates Hypoxia-Induced Keratinocyte Migration via the p38/MAPK Pathway 