Disruption of MAP7D1 Gene Function Increases the Risk of Doxorubicin-Induced Cardiomyopathy and Heart Failure

Table 1

MAP7D1 single nucleotide polymorphisms in patients with doxorubicin-induced cardiomyopathy.

			Association with maximum decline in LVEF
SNP ID	Gene	Location	Beta	SE	L95	U95	values
rs272825	MAP7D1	Intron	-27.24	6.62	-40.21	-14.27
rs272832	MAP7D1	Intron	-26.35	6.61	-40.20	-14.28
			1000 genome annotation
SNP ID	Gene	Location	Reference allele	Alternative allele	Asian AF	American AF	African AF	European AF
rs272825	MAP7D1	Intron	G	C	—	0.03	0.25	—
rs272832	MAP7D1	Intron	T	C	—	0.03	0.26	—

SNP: single nucleotide polymorphism; LVEF: left ventricular ejection fraction; SE: standard error; L95: lower bound 95; U95: upper bound 95; AF: allele frequency.