Mutation Profile Assessed by Next-Generation Sequencing (NGS) of Circulating Tumor DNA (ctDNA) in Chinese Lung Adenocarcinoma Patients: Analysis of Real-World Data

Table 5

Combinations of multiple gene coexistence mutations.

Mutation 1	Mutation 2	Mutation 3	Mutation 4	Number
EGFR 19 del	EGFR A750P			1
EGFR 19 del	EGFR E922V			1
EGFR 19 del	EGFR T790M			6
EGFR 19 del	EGFR T790M	EGFR gene amplification		1
EGFR 19 del	EGFR T790M	EGFR C797S		1
EGFR 19 del	EGFR gene amplification			3
EGFR 19 del	EGFR R689W			1
EGFR 19 del	EGFR S752			1
EGFR 20ins	EGFR~IGFBP3&LOC7 confusion	EGFR gene amplification		1
EGFR 20ins	EGFR V774			1
EGFR 21L858R	EGFR T790M			5
EGFR 21L858R	EGFR E790K			1
EGFR 21L858R	EGFR T790M	EGFR L62R		1
EGFR 21L858R	EGFR T790M	EGFR T725M	EGFR gene amplification	1
EGFR 21L885R	EGFR gene amplification			2
EGFR 21L858R	EGFR L62R			1
EGFR 21L858R	EGFR L833V			1
EGFR 19 del	PIK3CA E542K			1
EGFR 19 del	PIK3CA E545K			1
EGFR 19 del	PIK3CA E545K	EGFR T790M	EGFR C797S	1
EGFR 19 del	PIK3CA M1043	PTEN S59X	EGFR T790M	1
EGFR 21 L858R	PIK3CA E545K			1
EGFR 19 del	PTEN A126T			1
EGFR 19 del	PTEN L247fs	EGFR T790M		1
EGFR 19 del	HER2 gene amplification	EGFR gene amplification		1
EGFR 19 del	KRAS G13D			1
HER2 p.771insAYVM	PIK3CA P449L			1
KRAS G12C	PIK3C A H1047L			1
EGFR 19 del	NF1 S436fs			1
EGFR 19 del	HER2 R143Q			1
EGFR 19 del	MET gene amplification	EGFR E922V		1
Total				43