Prognostic and Clinicopathological Significance of Circular RNA circ-ITCH Expression in Cancer Patients: A Meta-analysis

Table 1

Characteristics of included studies in this meta-analysis.

First author (ref.)	Year	Cancer	Country	Sample size	Detection methods	Cutoff value	Clinicopathological features	HR (95% CI)	Data source	Follow-up time (months)	NOS score
Hao et al. [28]	2020	Oral squamous cell carcinoma	China	103	qRT-PCR	Median	①②	OS (U), 2.08 (1.26-3.46)	Curve	Up to 60	8
Lin et al. [24]	2020	Ovarian cancer	China	45	qRT-PCR	Median	①②③	OS (U), 2.36 (1.11-5.02)	Curve	Up to 60	8
Zhou et al. [32]	2020	Multiple myeloma	China	92	qRT-PCR	Median	NA	OS (U), 2.70 (1.15-6.25)	Direct	Median 24.5	7
Li et al. [27]	2019	Lung cancer	China	190	qRT-PCR	Median	①②③	OS (U), 2.27 (1.39-3.57)	Curve	Up to 36	8
Liang et al. [23]	2019	Ovarian cancer	China	122	qRT-PCR	NA	NA	OS (U), 2.86 (1.43-5.88) OS (M), 4.74 (1.40-16.13)	Direct	Median 30	6
Wang et al.^a [19]	2019	Prostate cancer	China	52	qRT-PCR	Median	①	OS (U), 3.85 (1.92-8.33)	Curve	Up to 70	8
Huang et al. [20]	2019	Prostate cancer	China	364	qRT-PCR	Median	①	OS (U), 2.50 (1.49-4.17) OS (M), 2.41 (1.42-4.08)	Direct	Up to 60	8
Ghasemi et al. [29]	2019	Gastric cancer	Iran	30	qRT-PCR	Median	①②③	NA	NA	NA	7
Wang et al.^b [26]	2019	Breast cancer	China	91	qRT-PCR	Median	①②③	OS (U), 2.44 (1.30-4.55)	Curve	Up to 100	8
Luo et al. [22]	2018	Ovarian cancer	China	77	qRT-PCR	Median	NA	OS (U), 4.76 (1.52-14.29) OS (M), 4.07 (1.16-14.29)	Direct	Median 28	7
Hu et al. [21]	2018	Ovarian cancer	China	20	qRT-PCR	NA	NA	OS (U), 2.27 (1.09-4.76)	Curve	Up to 140	6
Li et al. [31]	2018	Glioma	China	60	qRT-PCR	0.36	NA	OS (U), 3.33 (1.14-4.55) OS (M), 2.33 (1.20-5.43)	Direct	Up to 80	7
Yang et al. [25]	2018	Bladder cancer	China	70	qRT-PCR	NA	②③	OS (U), 1.89 (1.05-3.33)	Curve	1-60	7
Guo et al. [30]	2017	Hepatocellular carcinoma	China	288	qRT-PCR	Median	NA	OS (U), 2.22 (1.47-3.45)	Direct	Up to 90	7

NA: not available; qRT-PCR: quantitative reverse transcription-polymerase chain reaction; ①: lymph node metastasis (LNM); ②: TNM stage; ③: tumor size; OS: overall survival; U: univariate analysis; M: multivariate analysis; curve: Kaplan-Meier curve; the cutoff value of this study is 0.36 which was established by the receiver operating characteristic (ROC) analysis.