Identification of Multiple Hub Genes and Pathways in Hepatocellular Carcinoma: A Bioinformatics Analysis

Figure 2

Various results of bioinformatics analyses in DEGs and hub genes. (a) Volcano plot of the genome-wide detected in GSE14520. Red: upregulated; green: no difference; blue: downregulated. and were set as the threshold. (b) Heatmap of 1053 DEGs between HCC samples and normal tissues in GSE14520. The deeper the color, the more greatly the relative expression of DEGs goes up or down. Red: upregulated; blue: downregulated. (c) GO analysis of the down- and upregulated DEGs in HCC. The -axis presents significantly enriched GO annotation terms, and the -axis presents the different gene ratios. (d) The PPI networks of upregulated DEGs in HCC. (e) The PPI networks of downregulated DEGs in HCC. The orange nodes represent upregulated DEGs while the blue ones represent downregulated DEGs. The sizes of nodes mean the score levels of DEGs. A larger node represents a higher score. Solid line between two nodes represents the interaction between two DEGs. DEGs: differentially expressed genes; FDR: false discovery rate; FC: fold change; HCC: hepatocellular carcinoma; GO: Gene Ontology; PPI: protein-protein interaction.

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