Long Noncoding RNA FOXP4-AS1 Predicts Unfavourable Prognosis and Regulates Proliferation and Invasion in Hepatocellular Carcinoma

Table 2

Cox regression analyses of factors predicting disease-free survival and overall survival of HCC.

Characteristic	Training set			Validation set			Combined set
	HR	95% CI	value	HR	95% CI	value	HR	95% CI	value
DFS
Gender	1.174	0.506-2.727	0.708	1.024	0.446-2.355	0.955	2.447	0.874-6.849	0.088
Age	1.022	0.406-2.576	0.963	1.642	0.310-8.701	0.560	0.521	0.193-1.401	0.196
Family history	1.687	0.681-4.181	0.259	1.510	0.273-8.371	0.637	0.733	0.305-1.761	0.487
AFP	1.691	0.876-3.266	0.118	0.425	0.104-1.740	0.234	1.632	0.865-3.080	0.131
HBVDNA	2.353	1.038-5.337	0.041	0.546	0.135-2.204	0.395	2.010	1.019-3.965	0.044
Metastasis	1.226	0.482-3.116	0.668	2.370	0.502-11.177	0.276	1.129	0.519-2.456	0.760
Tumor diameter	1.515	0.557-4.117	0.416	4.458	0.466-42.604	0.194	0.956	0.421-2.171	0.914
FOXP4-AS1 expression	2.574	1.126-5.885	0.025	6.826	1.228-37.945	0.028	2.548	1.249-5.195	0.010
OS
Gender	1.208	0.522-2.796	0.659	1.163	0.498-2.718	0.727	1.384	0.617-3.101	0.430
Age	1.036	0.408-2.626	0.941	1.689	0.327-8.732	0.532	0.643	0.215-1.919	0.849
Family history	1.399	0.566-3.459	0.468	2.248	0.406-12.454	0.354	1.474	0.683-3.184	0.323
AFP	1.727	0.888-3.361	0.107	0.312	0.077-1.259	0.102	1.317	0.740-2.344	0.349
HBVDNA	3.086	1.366-7.127	0.008	0.384	0.091-1.622	0.193	1.676	0.864-3.250	0.127
Metastasis	2.003	0.772-5.198	0.153	2.829	0.602-13.285	0.188	1.309	0.612-2.801	0.487
Tumor diameter	1.204	0.418-3.465	0.730	6.600	0.633-68.799	0.115	1.667	0.674-4.120	0.269
FOXP4-AS1 expression	2.712	1.140-6.450	0.024	6.505	1.165-36.399	0.033	3.012	1.441-6.297	0.003

AFP: alpha-fetoprotein; HBVDNA: hepatitis B virus-dexoyribonucleic acid.