Intratumoral STING Agonist Injection Combined with Irreversible Electroporation Delays Tumor Growth in a Model of Hepatocarcinoma

Figure 3

Phenotypic and functional analysis of intratumor T lymphocytes in mice bearing PM299L tumors. Mice were challenged with PM299L tumor cells s.c. and at days 7-10, when tumors reached 5 mm in diameter, they were treated i.t. as indicated and sacrificed seven days later for phenotypic analysis of tumor-infiltrating lymphocytes. (a) Tumor area (measured with a caliper) and tumor weight measured in each individual mice the day of sacrifice. (b–g) Phenotypic and functional analysis of tumor-infiltrating T lymphocytes and NK cells measured by flow cytometry using the indicated antibodies. One-way ANOVA with Tukey’s multiple comparison test. p < 0.05; ; .

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