In Vivo and In Vitro Analyses of Titanium-Hydroxyapatite Functionally Graded Material for Dental Implants

Figure 2

Animal experiment design and micro-CT scan of Ti-HA FGM dental implants. (a) Design of the animal experiment. Implants were placed in the mandibles of beagle dogs 12 weeks after the premolars were extracted. After another 12 weeks of healing, the dogs were sacrificed. (b) Sample perioperative photograph. The dental implants were placed in the healing mandible of the dog. (c) Micro-CT and X-ray analyses were used to evaluate the changes in bone quality on the mesial and distal side of the implant and the peri-implant new bone formation at 4, 8, and 12 weeks after implant placement. At 4 weeks, the Ti-HA FGM dental implants had better bone quality around the implant compared with the Ti group. Up to 12 weeks, more peri-implant new bone formation was observed around the Ti-HA FGM dental implants than around the Ti implants.

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