ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway

Figure 3

The effect of ICT1 knockdown on osteosarcoma cell proliferation was reversed partly by BCL-2 overexpression. (a) Overexpression efficacy of BCL-2 in sh-ICT1 OS cells (U-2OS and 143B) was detected by western blotting. (b) Overexpression of BCL-2 partly reversed the suppressed effects of ICT1-knockdown on the CCK8 assay of U-2OS and 143B cells. Values are , (Student’s -test). (c) Overexpression of BCL-2 partly reversed the suppressed effects of ICT1-knockdown on the colony formation capability of U-2OS and 143B cells. Values are , , (Student’s -test). (d, e) Overexpression of BCL-2 partly reversed the induce effect of ICT1-knockdown on the apoptosis of OS cells (U-2OS and 143B). Values are , (Student’s -test).

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