NR3C2-Related Transcriptome Profile and Clinical Outcome in Invasive Breast Carcinoma

Table 2

Univariate/multivariate Cox regression analyses on the overall survival in BRCA.

Characteristics	Total ()	HR (95% CI)	value	HR (95% CI)	value
		Univariate analysis	Univariate analysis	Multivariate analysis	Multivariate analysis
Age (>60 vs. ≤60)	1064	2.036 (1.468-2.822)	<0.001	2.203 (1.197-4.055)	0.011
Anatomic neoplasm subdivisions (right vs. left)	1064	0.776 (0.559-1.077)	0.130
Menopause status (Pre&Peri vs. Post)	955	0.416 (0.250-0.692)	<0.001	0.899 (0.429-1.885)	0.777
Pathologic stage (Stage II&Stage III&Stage IV vs. Stage I)	1041	2.141 (1.270-3.609)	0.004	2.872 (1.077-7.656)	0.035
T stage (T2&T3&T4 vs. T1)	1061	1.435 (0.973-2.116)	0.069
N stage (N1&N2&N3 vs. N0)	1045	2.145 (1.497-3.073)	<0.001	2.065 (1.206-3.538)	0.008
M stage (M1 vs. M0)	909	4.327 (2.508-7.465)	<0.001	3.620 (1.597-8.205)	0.002
Radiation therapy (yes vs. no)	971	0.558 (0.381-0.819)	0.003	0.553 (0.344-0.887)	0.014
TP53 status (Mut vs. WT)	955	1.218 (0.858-1.730)	0.269
PIK3CA status (Mut vs. WT)	955	1.015 (0.696-1.479)	0.938
PAM50 (LumB&HER2&Basal vs. LumA)	1024	1.547 (1.109-2.158)	0.010	1.390 (0.851-2.272)	0.188
Race (Black or African American&Asian vs. White)	975	1.136 (0.765-1.687)	0.526
PR status (positive vs. negative)	1011	0.762 (0.541-1.074)	0.120
ER status (positive vs. negative)	1014	0.704 (0.487-1.017)	0.062
HER2 status (positive vs. negative)	705	1.611 (0.981-2.644)	0.059
Histological type (infiltrating ductal carcinoma vs. infiltrating lobular carcinoma)	959	1.162 (0.738-1.830)	0.516
NR3C2 (high vs. low)	1064	0.653 (0.468-0.911)	0.012	0.446 (0.268-0.743)	0.002