Association of BTLA Polymorphisms with Susceptibility to Non-Small-Cell Lung Cancer in the Chinese Population

Table 4

Logistic regression analyses of association of BTLA tagging polymorphisms with risk of NSCLC.

Genotype	Overall NSCLC cases () vs. controls ()				SCC () vs. controls ()				Non-SCC () vs. controls ()
	Crude OR (95% CI)		Adjusted OR^a (95% CI)		Crude OR (95% CI)		Adjusted OR^a (95% CI)		Crude OR (95% CI)		Adjusted OR^a (95% CI)
rs2171513 G>A
GA vs. GG	0.96 (0.79-1.17)	0.669	1.00 (0.81-1.24)	0.971	0.70 (0.46-1.05)	0.082	0.83 (0.51-1.32)	0.426	1.01 (0.82-1.24)	0.938	1.03 (0.83-1.28)	0.760
AA vs. GG	0.94 (0.59-1.49)	0.787	0.97 (0.60-1.59)	0.908	0.45 (0.14-1.47)	0.184	0.32 (0.09-1.18)	0.086	1.03 (0.64-1.66)	0.892	1.06 (0.65-1.74)	0.816
AA/GA vs. GG	0.96 (0.79-1.16)	0.637	1.00 (0.82-1.22)	1.00	0.67 (0.45-0.99)	0.044	0.74 (0.47-1.17)	0.195	1.01 (0.83-1.23)	0.912	1.04 (0.84-1.28)	0.728
AA vs. GG/GA	0.95 (0.60-1.51)	0.830	0.97 (0.60-1.58)	0.904	0.49 (0.15-1.62)	0.245	0.34 (0.09-1.23)	0.099	1.03 (0.65-1.65)	0.900	1.05 (0.64-1.72)	0.847
rs3112270 A>G
AG vs. AA	0.83 (0.69-1.01)	0.060	0.86 (0.70-1.05)	0.125	0.92 (0.64-1.33)	0.672	1.10 (0.72-1.69)	0.667	0.82 (0.67-1.00)	0.047	0.82 (0.67-1.01)	0.064
GG vs. AA	0.78 (0.55-1.11)	0.169	0.81 (0.56-1.18)	0.275	0.74 (0.35-1.53)	0.412	0.80 (0.35-1.85)	0.603	0.79 (0.54-1.14)	0.202	0.81 (0.55-1.20)	0.293
GG/AG vs. AA	0.83 (0.69-0.99)	0.038	0.85 (0.70-1.03)	0.092	0.90 (0.63-1.27)	0.535	1.05 (0.70-1.58)	0.818	0.81 (0.67-0.98)	0.033	0.82 (0.67-1.00)	0.051
GG vs. AA/AG	0.85 (0.60-1.19)	0.340	0.87 (0.61-1.25)	0.456	0.76 (0.37-1.56)	0.458	0.77 (0.34-1.73)	0.522	0.86 (0.60-1.23)	0.411	0.89 (0.61-1.29)	0.530
rs1982809 G>A
GA vs. GG	0.81 (0.67-0.98)	0.030	0.81 (0.66-0.99)	0.043	0.92 (0.63-1.33)	0.642	1.05 (0.68-1.62)	0.833	0.79 (0.65-0.97)	0.022	0.79 (0.64-0.97)	0.026
AA vs. GG	0.94 (0.65-1.35)	0.727	0.99 (0.68-1.45)	0.960	1.26 (0.66-2.40)	0.478	1.83 (0.84-3.97)	0.130	0.89 (0.61-1.30)	0.534	0.93 (0.63-1.39)	0.724
AA/GA vs. GG	0.83 (0.69-0.99)	0.042	0.84 (0.69-1.02)	0.071	0.97 (0.68-1.38)	0.850	1.15 (0.76-1.73)	0.522	0.81 (0.67-0.98)	0.026	0.81 (0.66-0.99)	0.037
AA vs. GG/GA	1.02 (0.72-1.45)	0.901	1.08 (0.74-1.57)	0.690	1.31 (0.70-2.45)	0.396	1.79 (0.84-3.80)	0.131	0.98 (0.67-1.41)	0.891	1.03 (0.70-1.51)	0.900
rs16859629 T>C
TC vs. TT	0.89 (0.68-1.15)	0.367	0.89 (0.68-1.18)	0.412	1.13 (0.70-1.84)	0.620	1.19 (0.68-2.11)	0.544	0.85 (0.64-1.12)	0.238	0.86 (0.65-1.15)	0.307
CC vs. TT	1.25 (0.40-3.96)	0.703	1.38 (0.41-4.58)	0.602	2.60 (0.50-13.53)	0.258	9.85 (1.37-71.03)	0.023	1.04 (0.30-3.59)	0.955	1.09 (0.30-4.01)	0.898
CC/TC vs. TT	0.90 (0.70-1.16)	0.419	0.91 (0.69-1.19)	0.486	1.18 (0.74-1.89)	0.481	1.31 (0.75-2.28)	0.338	0.86 (0.65-1.12)	0.253	0.87 (0.65-1.15)	0.330
CC vs. TT/TC	1.27 (0.40-4.02)	0.682	1.40 (0.42-4.66)	0.584	2.55 (0.49-13.25)	0.267	9.55 (1.32-68.66)	0.025	1.06 (0.31-3.68)	0.926	1.11 (0.30-4.09)	0.873

Notes: ^aadjusted for age, sex, smoking status, alcohol use, and BMI status in a logistic regression model.