Association of BTLA Polymorphisms with Susceptibility to Non-Small-Cell Lung Cancer in the Chinese Population
Table 5
Stratified analyses between BTLA rs1982809 G>A polymorphism and NSCLC risk by sex, age, smoking status, alcohol consumption, and BMI.
Variable
BTLA rs1982809 G>A (case/control)a
Adjusted ORb (95% CI);
GG
GA
AA
GG
GA vs. GG
AA vs. GG
GA/AA vs. GG
AA vs. (GG/GA)
Sex
Male
299/289
177/228
37/33
1.00
0.79 (0.60-1.05); : 0.100
1.32 (0.77-2.27); : 0.314
0.86 (0.66-1.11); : 0.246
1.45 (0.86-2.46); : 0.167
Female
267/182
174/133
34/30
1.00
0.87 (0.64-1.18); : 0.366
0.77 (0.45-1.33); : 0.352
0.85 (0.64-1.14); : 0.274
0.82 (0.49-1.38); : 0.457
Age
<59
254/203
173/162
31/28
1.00
0.93 (0.69-1.27); : 0.651
0.90 (0.50-1.62); : 0.728
0.93 (0.69-1.24); : 0.611
0.93 (0.52-1.64); : 0.799
≥59
312/268
178/199
40/35
1.00
0.75 (0.57-0.98); : 0.036
1.08 (0.65-1.78); : 0.778
0.79 (0.61-1.03); : 0.079
1.21 (0.74-1.98); : 0.450
Smoking status
Never
355/371
220/285
49/55
1.00
0.79 (0.62-1.01); : 0.060
0.91 (0.59-1.40); : 0.651
0.81 (0.65-1.02); : 0.074
1.00 (0.65-1.52); : 0.980
Ever
211/100
131/76
22/8
1.00
0.86 (0.59-1.26); : 0.444
1.32 (0.56-3.11); : 0.525
0.91 (0.63-1.31); : 0.603
1.40 (0.60-3.26); : 0.433
Alcohol consumption
Never
443/408
280/332
55/59
1.00
0.76 (0.61-0.94); : 0.013
0.87 (0.58-1.31); : 0.509
0.77 (0.63-0.95); : 0.016
0.98 (0.66-1.46); : 0.911
Ever
123/63
71/29
16/4
1.00
1.22 (0.70-2.14); : 0.479
2.55 (0.75-8.60); : 0.132
1.36 (0.80-2.32); : 0.256
2.37 (0.71-7.86); : 0.159
BMI (kg/m2)
<24
368/257
245/201
47/35
1.00
0.89 (0.68-1.15); : 0.361
1.06 (0.65-1.73); : 0.828
0.91 (0.71-1.17); : 0.458
1.11 (0.69-1.80); : 0.667
≥24
198/214
106/160
24/28
1.00
0.69 (0.50-0.97); : 0.030
0.88 (0.48-1.62); : 0.677
0.72 (0.53-0.99); : 0.041
1.01 (0.56-1.84); : 0.973
Notes: athe genotyping was successful in 1,003 (98.50%) NSCLC cases, and 901 (99.33%) controls for BTLA rs1982809 G>A. bAdjusted for age, sex, smoking status, alcohol consumption, and BMI (besides stratified factors accordingly) in a logistic regression model. Abbreviations: BMI: body mass index; NSCLC: non-small-cell lung cancer.
