Association of BTLA Polymorphisms with Susceptibility to Non-Small-Cell Lung Cancer in the Chinese Population
Table 7
Stratified analyses between BTLA rs3112270 A>G polymorphism and NSCLC risk by sex, age, smoking status, alcohol consumption, and BMI.
Variable
BTLA rs3112270 A>G (case/control)a
Adjusted ORb (95% CI);
AA
GA
GG
AA
AG vs. AA
GG vs. AA
AG/GG vs. AA
GG vs. (AA/AG)
Sex
Male
277/270
199/237
37/43
1.00
0.89 (0.68-1.17); : 0.413
0.97 (0.58-1.62); : 0.902
0.90 (0.69-1.18); : 0.447
1.02 (0.62-1.68); : 0.940
Female
250/165
193/151
31/29
1.00
0.84 (0.62-1.13); : 0.257
0.72 (0.41-1.26); : 0.250
0.82 (0.62-1.09); : 0.179
0.78 (0.45-1.34); : 0.367
Age
<59
243/195
184/163
31/35
1.00
0.92 (0.68-1.26); : 0.615
0.81 (0.47-1.43); : 0.472
0.91 (0.68-1.21); : 0.507
0.84 (0.49-1.45); : 0.539
≥59
284/240
208/225
37/37
1.00
0.82 (0.63-1.07); : 0.140
0.84 (0.50-1.39); : 0.493
0.82 (0.63-1.06); : 0.131
0.92 (0.56-1.51); : 0.733
Smoking status
Never
330/339
246/316
47/56
1.00
0.81 (0.64-1.03); : 0.081
0.87 (0.56-1.35); : 0.528
0.82 (0.65-1.03); : 0.084
0.96 (0.63-1.46); : 0.836
Ever
197/96
146/72
21/16
1.00
1.01 (0.69-1.47); : 0.980
0.67 (0.33-1.37); : 0.278
0.94 (0.66-1.36); : 0.758
0.67 (0.34-1.35); : 0.263
Alcohol consumption
Never
410/383
312/350
56/66
1.00
0.85 (0.69-1.06); : 0.156
0.78 (0.52-1.17); : 0.230
0.84 (0.69-1.04); : 0.106
0.84 (0.57-1.24); : 0.380
Ever
117/52
80/38
12/6
1.00
0.89 (0.52-1.52); : 0.666
1.14 (0.38-3.46); : 0.818
0.92 (0.55-1.54); : 0.747
1.20 (0.41-3.55); : 0.742
BMI (kg/m2)
<24
355/233
255/217
49/43
1.00
0.79 (0.61-1.02); : 0.070
0.81 (0.51-1.29); : 0.369
0.79 (0.62-1.01); : 0.063
0.90 (0.57-1.41); : 0.646
≥24
172/202
137/171
19/29
1.00
0.96 (0.70-1.32); : 0.787
0.82 (0.34-1.55); : 0.543
0.94 (0.69-1.27); : 0.677
0.84 (0.45-1.56); : 0.574
Notes: athe genotyping was successful in 1,003 (98.40%) NSCLC cases, and 901 (99.33%) controls for BTLA rs3112270 A>G; badjusted for age, sex, smoking status, alcohol consumption, and BMI (besides stratified factors accordingly) in a logistic regression model. Abbreviations: BMI: body mass index; NSCLC: non-small-cell lung cancer.
