Association of BTLA Polymorphisms with Susceptibility to Non-Small-Cell Lung Cancer in the Chinese Population
Table 8
Stratified analyses between BTLA rs16859629 T>C polymorphism and NSCLC risk by sex, age, smoking status, and alcohol consumption.
Variable
BTLA rs16859629 T>C (case/control)a
Adjusted ORb (95% CI);
TT
TC
CC
TT
TC vs. TT
CC vs. TT
TC/CC vs. TT
CC vs. (TT/TC)
Sex
Male
435/459
70/81
3/1
1.00
0.91 (0.63-1.33); : 0.636
5.89 (0.56-61.95); : 0.140
0.96 (0.66-1.39); : 0.815
5.97 (0.57-62.73); : 0.137
Female
400/287
61/51
4/4
1.00
0.85 (0.57-1.29); : 0.455
0.70 (0.17-2.89); : 0.618
0.84 (0.57-1.26); : 0.402
0.71 (0.17-2.95); : 0.640
Age
<59
387/325
58/58
4/3
1.00
0.80 (0.52-1.22); : 0.303
1.17 (0.24-5.76); : 0.848
0.82 (0.54-1.24); : 0.342
1.21 (0.45-5.93); : 0.819
≥59
448/421
73/74
3/2
1.00
0.96 (0.67-1.39); : 0.843
1.56 (0.24-10.30); : 0.643
0.98 (0.68-1.41); : 0.908
1.57 (0.24-10.35); : 0.639
Smoking status
Never
527/593
80/107
6/5
1.00
0.85 (0.61-1.18); : 0.325
1.21 (0.35-4.19); : 0.766
0.87 (0.63-1.19); : 0.376
1.24 (0.36-4.29); : 0.738
Ever
308/153
51/25
1/0
1.00
1.00 (0.59-1.70); : 0.988
-
1.02 (0.60-1.72); : 0.945
-
Alcohol consumption
Never
659/665
102/117
6/5
1.00
0.89 (0.66-1.21); : 0.457
1.24 (0.36-4.31); : 0.734
0.91 (0.68-1.22); : 0.513
1.26 (0.36-4.37); : 0.715
Ever
176/81
29/15
1/0
1.00
0.86 (0.42-1.75); : 0.681
-
0.89 (0.44-1.80); : 0.735
-
BMI (kg/m2)
<24
557/411
88/71
4/2
1.00
0.92 (0.65-1.32); : 0.658
1.81 (0.30-10.83); : 0.514
0.95 (0.67-1.34); : 0.752
1.84 (0.31-10.95); : 0.505
≥24
278/335
43/61
3/3
1.00
0.83 (0.53-1.29); : 0.411
1.08 (0.20-5.86); : 0.930
0.84 (0.55-1.30); : 0.437
1.11 (0.20-6.00); : 0.906
Notes: athe genotyping was successful in 1,003 (97.01%) NSCLC cases, and 901 (98.00%) controls for BTLA rs16859629 T>C; badjusted for age, sex, smoking status, alcohol consumption, and BMI (besides stratified factors accordingly) in a logistic regression model. Abbreviations: BMI: body mass index; NSCLC: non-small-cell lung cancer.
