Ginsenoside CK Inhibits TGF-β-Induced Epithelial-Mesenchymal Transition in A549 Cell via SIRT1

Figure 4

Effects of ginsenoside CK on lung metastasis in vivo. Female BALB/c nude mice were injected via the tail vein with A549 cells and were orally administered with 10 mg·kg^-1 or 20 mg·kg^-1 ginsenoside CK for 3 weeks. (a) Bioluminescence imaging of the mice after injection at weeks 1, 2, and 3. Bioluminescence of the lung is shown. (b) Mean bioluminescence of the lung in tail vein pulmonary metastasis mice at 3 weeks. (c) Representative images of lung metastatic nodules. (d) Representative pictures of HE staining of the lung tissue are shown (magnification, (A) ×100 and (B ×400). .

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