The Association between Five Genetic Variants in MicroRNAs (rs2910164, rs11614913, rs3746444, rs11134527, and rs531564) and Cervical Cancer Risk: A Meta-Analysis

Table 2

Summary of pooled ORs in the meta-analysis.

		OR		OR		OR		OR		OR
miRNA-146a		C/G		GC/GG		CC/GG		GC+CC/GG		CC/GC+GG
Overall	6	1.08 (0.90-1.30)	0.001	0.94 (0.76-1.15)	0.140	0.85 (0.57-1.26)	0.001	0.90 (0.70-1.15)	0.014	0.90 (0.68-1.19)	0.002
Sample size
Large	4	1.13 (0.91-1.40)	0.001	0.88 (0.67-1.16)	0.072	0.77 (0.49-1.20)	0.001	0.83 (0.60-1.15)	0.012	0.86 (0.64-1.16)	0.003
Small	2	0.96 (0.59-1.57)	0.038	1.08 (0.78-1.50)	0.390	1.22 (0.37-4.04)	0.029	1.06 (0.67-1.69)	0.132	1.17 (0.40-3.41)	0.043
HWE
	5	1.06 (0.86-1.31)	0.000	0.93 (0.73-1.19)	0.083	0.88 (0.56-1.39)	0.000	0.91 (0.67-1.22)	0.007	0.93 (0.69-1.27)	0.001
	1	1.24 (0.88-1.74)	—	0.91 (0.55-1.52)	—	0.68 (0.36-1.31)	—	0.83 (0.53-1.31)	—	0.71 (0.38-1.32)	—
miRNA-196a2		C/T		TC/TT		CC/TT		TC+CC/TT		CC/TC+TT
Overall	6	0.83 (0.67-1.04)	0.000	1.19 (0.90-1.58)	0.001	1.41 (0.94-2.10)	0.000	1.28 (0.93-1.75)	0.000	1.23 (0.97-1.57)	0.021
Sample size
Large	4	0.92 (0.84-1.02)	0.284	1.06 (0.86-1.31)	0.106	1.19 (1.00-1.41)	0.369	1.10 (0.90-1.33)	0.112	1.12 (0.97-1.29)	0.676
Small	2	0.62 (0.22-1.78)	0	1.91 (0.52-7.08)	0.001	2.24 (1.32-15.50)	0.000	2.12 (0.44-10.21)	0.000	1.49 (0.49-4.52)	0.006
HWE
	5	0.93 (0.85-1.02)	0.336	1.06 (0.89-1.26)	0.182	1.16 (0.99-1.37)	0.394	1.08 (0.92-1.28)	0.173	1.10 (0.96-1.27)	0.681
	1	0.36 (0.26-0.51)	—	3.81 (1.97-7.37)	—	5.99 (3.09-11.59)	—	4.80 (2.62-8.76)	—	2.57 (1.59-4.15)	—
miRNA-499		G/A		AG/AA		GG/AA		AG+GG/AA		GG/AG+AA
Overall	4	0.76 (0.50-1.15)	0	1.34 (0.82-2.20)	0.001	1.42 (0.61-3.30)	0	1.42 (0.83-2.42)	0	1.27 (0.68-2.35)	0.002
Sample size
Large	2	0.86 (0.58-1.27)	0.025	1.34 (0.65-2.75)	0.001	1.03 (0.66-1.60)	0.705	1.28 (0.70-2.35)	0.003	0.99 (0.64-1.53)	0.413
Small	2	0.68 (0.27-1.72)	0	1.34 (0.52-3.48)	0.035	2.01 (0.35-11.56)	0	1.58 (0.44-5.63)	0.002	1.67 (0.55-5.05)	0.001
HWE
	2	0.67 (0.28-1.58)	0	1.36 (0.61-3.00)	0.007	2.28 (0.52-9.98)	0	1.64 (0.54-5.01)	0	1.80 (0.69-4.74)	0.006
	2	0.86 (0.55-1.36)	0.048	1.33 (0.56-3.16)	0.029	0.84 (0.50-1.43)	0.886	1.26 (0.59-2.70)	0.035	0.89 (0.60-1.34)	0.583
miRNA-218		G/A		AG/AA		GG/AA		AG+GG/AA		GG/AG+AA
Overall	4	0.98 (0.83-1.15)	0.003	1.07 (0.89-1.29)	0.053	1.01 (0.73-1.40)	0.006	1.06 (0.86-1.31)	0.010	0.97 (0.76-1.23)	0.035
Sample size
Large	4	0.98 (0.83-1.15)	0.003	1.07 (0.89-1.29)	0.053	1.01 (0.73-1.40)	0.006	1.06 (0.86-1.31)	0.010	0.97 (0.76-1.23)	0.035
Small	0	—	—	—	—	—	—	—	—	—	—
HWE
	3	1.03 (0.88-1.21)	0.019	0.99 (0.88-1.13)	0.318	0.92 (0.66-1.28)	0.021	0.97 (0.82-1.16)	0.091	0.92 (0.69-1.24)	0.031
	1	0.79 (0.63-0.98)	—	1.53 (1.09-2.15)	—	1.43 (0.94-2.16)	—	1.49 (1.09-2.05)	—	1.15 (0.79-1.66)	—
miRNA-124		C/G		GC/GG		CC/GG		GC+CC/GG		CC/GC+GG
Overall	3	0.58 (0.40-0.83)	0.097	1.27 (0.97-1.66)	0.899	2.87 (1.40-5.91)	0.887	1.38 (1.07-1.80)	0.409	2.26 (1.58-3.23)	0.979
Sample size
Large	2	0.46 (0.32-0.66)	0.858	1.70 (0.47-6.17)	0.967	3.63 (1.04-12.63)	0.996	3.13 (0.90-10.85)	0.995	2.24 (1.51-3.31)	0.860
Small	1	0.75 (0.59-0.95)	—	1.25 (0.95-1.64)	—	2.48 (1.02-6.04)	—	1.32 (1.01-1.72)	—	2.36 (0.97-5.74)	—
HWE
	3	0.58 (0.40-0.83)	0.097	1.27 (0.97-1.66)	0.899	2.87 (1.40-5.91)	0.887	1.38 (1.07-1.80)	0.035	2.26 (1.58-3.23)	0.979
	0	—	—	—	—	—	—	—	—	—	—