PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury

Figure 1

PICK1 was increased in LPS-induced AKI models both in vitro and in vivo. (a, b) PCR and western blotting results after treatment with different concentrations of LPS for 24 hours (0 μg/ml versus 5 μg/ml, 0 μg/ml versus 15 μg/ml; , ). (c) Western blotting results after LPS treatment for different times (0 h versus 12 h, 0 h versus 24 h; , ). (d, e) Representative immunohistochemical images of pretreated renal tissue (magnification ×400,  μm, the control versus LPS, ). (f) Representative western blotting analysis showed the expression of PICK1 in the kidney of mice treated with LPS (10 mg/kg) and FSC231 (78.4 μg/g) (the control versus LPS, ).

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