PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury

Figure 4

Knockdown of PICK1 increased the production of peroxide and activated the apoptotic pathway after LPS treatment. (a) After treatment with LPS for 24 hours, the content of GSH in the NC and sh-PICK1 groups (NC versus sh-PICK1, ). (b) The content of GSH in each group of mouse model (LPS versus LPS+FSC231, ). (c) Representative fluorescence images of ROS. (d, e) Representative western images of the ASK1 and p38MAPK pathway (NC versus sh-PICK1, ; ASK1: the control versus LPS, ; LPS versus LPS+FSC231, ; p38MAPK: the control versus LPS, ; LPS versus LPS+FSC231, ).

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