The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Higher Body Mass Index and Fasting Glucose Levels: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the selected studies.

Author	Published year	Age composition	Sex composition (%female)	Number of Thr/Thr	Number of Thr/Ala	Number of Ala/Ala	Ala-allele frequency (%)	Metabolic parameters
Mentuccia	2002		100.00%	52	66	17	37.04%	BMI, fasting glucose, fasting insulin
Gumieniak	2007	18-65	43.60%	143	175	54	38.04%	Hypertension prevalence, fasting glucose, fasting insulin
van der Deure WM (a)	2009		60.66%	521	634	169	36.71%	Hypertension prevalence
van der Deure WM (b)	2009		50.65%	376	459	135	37.58%	Hypertension prevalence
Butler	2010	18-65	60.00%	15	15	15	50.00%	BMI, fasting glucose, fasting insulin, TC, TG, HDL
Sotak	2018	20-92	63.00%	196	152	52	32.00%	BMI, fasting glucose, fasting insulin
Kang	2019	50-69	47.94%	1991	2967	1064	42.30%	BMI, TC, TG, HDL

The studies of van der Deure WM (a) and (b) represent the Rotterdam Study and the Rotterdam Scan Study, respectively. Age composition is expressed as or age range. BMI, TC, TG, HDL, respectively, represent body mass index, total cholesterol, total triglyceride, and high-density lipoprotein cholesterol.