Abrus precatorius Leaf Extract Reverses Alloxan/Nicotinamide-Induced Diabetes Mellitus in Rats through Hormonal (Insulin, GLP-1, and Glucagon) and Enzymatic (α-Amylase/α-Glucosidase) Modulation

Table 3

Effect of APLE on number of pancreatic islets and median pancreatic area of Alloxan/nicotinamide-induced diabetic rats.

Treatment groups	Number of islets	Median area (×10^3μm^2; Q1-Q3)	Average rank
Control	16	5.299 (2.047-9.996)	65.0
Model	16^ns	3.131 (1.445-6.142)^a	34.9
Metformin (300 mg/kg)	18^ns	4.336 (2.348-7.587)^ns	50.6
APLE (mg/kg)
100	27^b	7.467 (5.299-9.635)^b	76.0
200	25^b	7.949 (6.624-9.153)^b	83.2
400	35^b	7.949 (6.744-9.394)^b	80.3

^a (model vs control); ^b (APLE and metformin vs. model); APLE: Abrus precatorius leaf extract; ns: not significant.