Review Article
The Effect of Letrozole Combined with Dydrogesterone for Endometriosis in China: A Meta-Analysis
Table 1
Details of included studies.
| | Source | Study design | Number (T/C) | Age (T/C) | Interventions(T/C) | Intervention time | Outcome indicators |
| | Liu Yanping 2020 [14] | RCT | 53/53 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①②③ | | Wang Jin 2020 [15] | RCT | 40/40 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ②④⑤⑥ | | Zhang Ji 2019 [16] | RCT | 30/30 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①③④⑤⑥ | | Xie Ailing 2019 [17] | RCT | 35/35 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ②⑥⑦ | | Li Xinzhou 2019 [18] | RCT | 60/60 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ① | | Liu Zhongjing 2019 [19] | RCT | 32/32 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①②③④⑤⑥ | | Zhao Yazheng 2019 [20] | RCT | 40/40 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①④⑤⑥ | | Zhang Wei 2019 [21] | RCT | 30/30 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①②⑧⑨ | | Wang Lina 2019 [22] | RCT | 43/43 | - | Letrozole combined with dydrogesterone/letrozole | 6 months | ①②③④⑤⑥ | | Bai Yingxiao 2019 [23] | RCT | 75/75 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①②⑧⑨ | | Tan Xifeng 2019 [24] | RCT | 49/49 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①②③④⑤⑥⑦⑧⑨ | | Cao Ning 2018 [25] | RCT | 42/42 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①②⑧⑨ | | Lian Jianmei 2018 [26] | RCT | 42/42 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①②③④⑤⑥ | | Chen Wenling 2018 [27] | RCT | 46/46 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①③④⑤⑥ | | Hu Yanrong 2017 [28] | RCT | 30/30 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①②③⑥ | | Chen Xiaohong 2019 [29] | RCT | 34/33 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ① | | Yue Hongli 2020 [30] | RCT | 33/33 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①②③⑥ | | Liang Jing 2017 [31] | RCT | 30/30 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ①②③ | | Chen Jianli 2020 [32] | RCT | 52/52 | / | Letrozole combined with dydrogesterone/letrozole | 6 months | ②③④⑤⑥ |
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T: the experiment group; C: the control group; -: not mentioned; RCT: randomized controlled trial; ①: total effectiveness; ②: VEGF level; ③: CA125 level; ④: FSH level; ⑤: LH level; ⑥: E2 level; ⑦: P level; ⑧: IL-6 level; ⑨: TNF-a level; VEGF: Vascular Endothelial Growth Factor; CA125: Carbohydrate Antigen 125; FSH: Follicle-Stimulating Hormone; LH: Luteinizing Hormone; E2: estrogen; P: progesterone; IL-6: interleukin-6; TNF-a: tumor necrosis factor-a.
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