Development of a KRAS-Associated Metabolic Risk Model for Prognostic Prediction in Pancreatic Cancer

<div>Association between the risk model and metabolic characteristics of pancreatic cancer (PC). (a) Enrichment analysis of 6 PAGs showed the potential metabolic pathways involved. (b) The expression levels of several KRAS-driven metabolic genes between high-risk and low-risk groups in TCGA cohort. Higher expressions of PKM (<span class="nowrap"><svg height="11.7782pt" id="M41" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 75.9257 11.7782" width="75.9257pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.342,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.605,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 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BioMed Research International

fig7

Figure 7

Figure 7: Development of a KRAS-Associated Metabolic Risk Model for Prognostic Prediction in Pancreatic Cancer 