Research Article
Relationship between CRP Albumin Ratio and the Mortality in Critically Ill Patients with AKI: A Retrospective Observational Study
Table 1
Characteristics of the study patients according to CAR.
| | Characteristics | CRP to albumin ratio | value | | 0-0.2 () | 0.21-2.53 () | 2.54-16.43 () |
| | Age (years) | | | | <0.001 | | Gender ( (%)) | | | | 0.022 | | Male | 111 (57.5%) | 121 (63.4%) | 139 (70.9%) | | | Female | 82 (42.5%) | 70 (36.6%) | 57 (29.1%) | | | CAR | 0.0 (0.0-0.1) | 0.9 (0.4-1.7) | 5.1 (3.7-7.6) | <0.001 | | Respiratory rate (beats/minute) | | | | <0.001 | | Temperature (°C) | | | | 0.036 | | Heart rate (beats/minute) | | | | 0.266 | | MAP (mmHg) | | | | 0.08 | | Laboratory parameters | | | | | | Albumin (g/L) | | | | <0.001 | | CRP (mg/L) | 1.5 (0.7-2.9) | 5.9 (12.5-54.7) | 151.4 (110.5-205.0) | <0.001 | | BUN (mmol/L) | 6.1 (4.6-9.0) | 7.6 (5.2-12.6) | 8.0 (5.3-12.5) | <0.001 | | Chloride (mmol/L) | | | | 0.005 | | Creatinine (μmol/L) | 154.4 (118.0-211.9) | 179.5 (124.4-254.8) | 182.8 (131.0-252.0) | 0.029 | | Glucose (mmol/L) | 5.4 (4.9-7.0) | 6.4 (5.2-8.5) | 7.0 (5.3-10.0) | <0.001 | | Potassium (mmol/L) | | | | 0.017 | | Sodium (mmol/L) | | | | 0.001 | | Triglycerides (mmol/L) | 1.2 (0.9-1.8) | 1.3 (0.9-1.9) | 1.4 (0.9-2.1) | 0.151 | | BMG (mg/L) | 2.5 (1.9-3.5) | 3.0 (2.2-5.1) | 3.0 (2.2-5.6) | <0.001 | | Hematocrit (%) | | | | 0.002 | | Hemoglobin (g/L) | | | | <0.001 | | MCV (fL) | | | | 0.017 | | Platelets (109/L) | 176.0 (135.0-227.0) | 187.0 (116.0-232.0) | 181.0 (103.5-248.0) | 0.896 | | RBC (1012/L) | | | | 0.002 | | RDW (%) | | | | 0.005 | | WBC (109/L) | 6.4 (5.1-8.9) | 8.9 (5.9-12.2) | 9.5 (6.5-13.9) | <0.001 | | TBIL (μmol/L) | 13.9 (10.2-19.7) | 15.2 (10.8-22.5) | 15.9 (10.9-26.5) | 0.047 | | Scoring systems | | | | | | APACHE II | 12.0 (8.0-17.0) | 15.0 (10.0-20.0) | 18.0 (12.0-23.0) | <0.001 | | SOFA | 4.0 (2.0-5.0) | 5.0 (3.0-7.5) | 5.0 (3.0-8.0) | <0.001 | | Comorbidities ( (%)) | | | | | | Hypertension | 93 (48.2%) | 73 (38.2%) | 111 (56.6%) | 0.001 | | Diabetes | 43 (22.3%) | 32 (16.8%) | 37 (18.9%) | 0.383 | | Coronary artery disease | 23 (11.9%) | 16 (8.4%) | 37 (18.9%) | 0.008 | | Acute cerebral infarction | 26 (13.5%) | 15 (7.9%) | 27 (13.8%) | 0.127 | | Cancer | 3 (1.6%) | 4 (2.1%) | 13 (6.6%) | 0.011 | | Surgical grade ( (%)) | | | | <0.001 | | No surgery or grade 1 | 51 (26.4%) | 81 (42.4%) | 66 (33.7%) | | | Grade 2 | 44 (22.8%) | 17 (8.9%) | 15 (7.7%) | | | Grade 3 | 15 (7.8%) | 11 (5.8%) | 10 (5.1%) | | | Grade 4 | 83 (43.0%) | 82 (42.9%) | 105 (53.6%) | | | AKI stage ( (%)) | | | | 0.037 | | Stage 1 | 138 (71.5%) | 115 (60.2%) | 115 (58.7%) | | | Stage 2 | 33 (17.1%) | 55 (28.8%) | 56 (28.6%) | | | Stage 3 | 22 (11.4%) | 21 (11.0%) | 25 (12.8%) | | | ICU LOS (days) | 4.0 (2.0-9.0) | 7.0 (3.5-12.0) | 9.0 (4.0-15.0) | <0.001 | | Recovery from AKI ( (%)) | 141 (73.1%) | 129 (66.8%) | 106 (54.6%) | <0.001 | | Hospital mortality ( (%)) | 28 (14.5%) | 43 (22.5%) | 75 (38.3%) | <0.001 | | 2-year mortality ( (%)) | 46 (36.2%) | 69 (57.5%) | 101 (69.7%) | <0.001 |
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CAR: C-reactive protein-to-albumin ratio; CRP: C-reactive protein; MAP: mean arterial pressure; BUN: blood urea nitrogen; BMG: β2-microglobulin; MCV: mean corpuscular volume; RBC: red blood cells; RDW: red cell distribution width; WBC: white blood cells; TBIL: total bilirubin; SOFA: sequential organ failure assessment; APACHE II: acute physiological and chronic health score II; AKI: acute kidney injury; ICU: intensive care unit; LOS: length of stay.
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