Taurine-Upregulated Gene 1 Attenuates Cerebral Angiogenesis following Ischemic Stroke in Rats

<div>TUG1 antagonizes the promotion of VEGF by miR-26a to regulate neurological functional recovery and cerebral angiogenesis in MCAO rats. (a) Neurological function of MCAO rats in various treatment groups. (b) Relative VEGF mRNA levels in MCAO rats in various groups. (c) Images from IHC photographs of VEGF in various groups (400x). (d) Expression of CD31 and count of MVD in brain samples of MCAO rats in various groups. Magnification of the microphotograph, ×400. (e) VEGF and CD31 protein expression among each group. 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205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>,</span> compared with the miR-26a mimics+pcDNA-NC group; <sup>###</sup><span class="nowrap"><svg height="9.2729pt" id="M51" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 51.1027 9.2729" width="51.1027pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.658,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.921,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 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499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>,</span> compared with the miR-26a mimics+pcDNA-NC group.</div>

BioMed Research International

fig5

Figure 5

Figure 5: Taurine-Upregulated Gene 1 Attenuates Cerebral Angiogenesis following Ischemic Stroke in Rats 