Review Article
Updates on Quantitative MRI of Diffuse Liver Disease: A Narrative Review
Table 1
Magnetic resonance imaging studies on diffusion-weighted imaging for diffuse liver disease.
| Study | patients | Objective | Model performance | Reference standard | Nature of study |
| Guiu et al., Radiol. [50] | 108 | , , and values derived from IVIM in steatosic livers vs. normal livers |
| Clinical assessment of type 2 diabetes | Monocentric Prospective | Murphy et al., J Magnetic Resonance Imaging [51] | 89 | Associations between histologic alterations and DWI in NAFLD | | Liver biopsy | Monocentric Prospective observational | Lewin et al., Hepatology [52] | 74 | DWI in predicting fibrosis or cirrhosis vs. healthy volunteers | | Liver biopsy | Monocentric Prospective | Taouli et al., AJR American Journal of Roentgenology [53] | 30 | ADC in quantification of liver fibrosis at different stages |
| Liver biopsy | Monocentric Prospective | Yoon et al., Journal of Computer Assisted Tomography[54] | 55 | IVIM parameters (, , and ) vs. ADC in hepatic fibrosis (F0-1 vs. F4) |
| Liver biopsy | Monocentric Retrospective | Akpinar et al., Journal of Medical Imaging and Radiation Oncology [56] | 55 | ADC to assess iron overload in β-thalassemia major patients vs. iron overload MRI sequences | | Laboratory blood test for β-thalassemia major diagnosis | Monocentric Retrospective | Kovač et al., Acta Radiologica[58] | 108 | ADC in primary sclerosing cholangitis |
| MRI | Monocentric Prospective |
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D: diffusion coefficient; D : pseudodiffusion coefficient; f: microperfusional fraction; DWI: diffusion-weighted imaging; NAFLD: nonalcoholic fatty liver disease; ADC: apparent diffusion coefficient; AUC: area under the curve; IVIM: intravoxel incoherent motion. |