Comparison between Clinical Utility of CXCL-8 and Clinical Practice Tumor Markers for Colorectal Cancer Diagnosis

Table 4

Relationship between the serum CXCL-8, CEA, and CA19-9 levels and the clinicopathological features of patients with colorectal cancer.

Clinicopathological characteristics	No. subjects	CXCL-8 (pg/mL)	CEA (ng/mL)	CA19-9 (U/mL)
Location
Colon	122	37.58 (27.36–55.68)	3.90 (2.20–8.63)	14.28 (7.98–27.09)
Rectum	105	37.75 (29.12–62.14)	3.00 (1.80–6.80)	14.17 (8.48–23.74)
value		0.458	0.111	0.580
TNM stage
I	42	37.66 (28.56–56.82)	2.60 (1.48–4.75)	13.78 (7.62–23.59)
II	83	36.27 (27.38–62.06)	3.20 (2.00–8.60)	13.36 (7.50–25.86)
III	85	36.83 (28.12–56.98)	3.70 (2.10–7.75)	14.36 (9.40–24.45)
IV	17	53.38 (35.24–71.14)	8.40 (4.75–38.50)	22.71 (12.11–109.40)
value		0.423	<0.001	0.073
T stage
T1	11	38.98 (33.83–67.80)	1.50 (1.20–2.90)	11.21 (1.33–19.96)
T2	34	35.96 (28.93–55.05)	2.92 (1.80–5.78)	14.30 (8.77–23.59)
T3	154	36.33 (27.38–55.38)	3.60 (2.08–8.40)	13.86 (7.98–25.87)
T4	28	41.61 (31.35–69.72)	6.65 (2.35–20.68)	20.12 (11.60–48.44)
value		0.416	0.001	0.077
N stage
N0	123	36.27 (27.42–54.69)	2.90 (1.80–5.70)	13.65 (7.75–24.39)
N1	60	47.16 (31.39–78.31)	3.90 (2.45–9.05)	13.94 (9.27–24.70)
N2	44	35.95 (28.16–51.60)	4.90 (2.00–11.65)	17.12 (11.05–27.54)
value		0.062	0.016	0.260
M stage
M0	206	36.33 (27.72–55.38)	3.20 (1.90–6.20)	13.91 (8.14–23.46)
M1	21	53.38 (37.52–65.47)	8.40 (4.20–28.52)	23.52 (12.72–77.58)
value		0.039	<0.001	0.007
Histological grade
High	6	39.52 (32.71–66.49)	3.25 (2.20-4.30)	15.83 (8.62-22.43)
Moderate	206	37.66 (27.92–57.85)	3.40 (1.90-7.60)	13.91 (8.00-25.04)
Low	15	40.94 (35.28–55.24)	4.70 (1.95-14.65)	22.71 (14.34-36.18)
value		0.718	0.621	0.095
Vascular invasion
Present	41	38.15 (26.34–56.93)	4.20 (2.20–8.70)	16.60 (9.16–3.19)
Absent	175	38.16 (28.69–64.66)	3.35 (1.90–7.20)	13.84 (7.87–23.49)
Unknown	11	35.97 (32.71–37.63)	4.15 (2.60–6.10)	19.11 (13.96–25.04)
value		0.638	0.523	0.082
Nerve invasion
Present	66	39.42 (28.85–76.51)	4.20 (2.60–14.40)	15.00 (9.16–35.27)
Absent	155	36.98 (27.63–53.46)	3.00 (1.80–5.95)	13.86 (7.83–22.76)
Unknown	5	56.11 (37.52–81.40)	3.00 (2.90–5.30)	19.96 (8.40–22.71)
value		0.184	0.007	0.165
Tumor size (cm)
<5	129	36.11 (27.72–53.54)	2.90 (1.80–5.70)	14.50 (8.14–23.46)
≥5	98	42.80 (29.02–76.20)	4.15 (2.40–9.40)	13.84 (8.80–32.91)
value		0.034	0.009	0.294

Data are presented as the median with the interquartile range and are statistically significant at (bold).