[Retracted] In Vitro Evaluation of Cytotoxic Potential of Caladium lindenii Extracts on Human Hepatocarcinoma HepG2 and Normal HEK293T Cell Lines

Figure 2

Morphological representation of HepG2 cells following the exposure of increasing concentrations of ethanolic extract of C. lindenii at 72 h observed by Floid cell imaging station. Changes in the morphology of hepatocellular carcinoma (HepG2) cells are very obvious when exposed to ethanolic concentrations. (a) The concentration of 50 μg/mL and higher changed the normal morphology and the cell adhesion capability to the surface as compared to the control. Higher cellular concentrations give the impression of clusters. The lower concentration (10 μg/mL) did not show altered shape or reduced viability in HepG2 cells as observed by the MTT assay. Application of cisplatin (positive control) changed the morphology of both cancerous and healthy cells round-shaped with less viability. (b) The morphological features and cytotoxicity of C. lindenii on normal cells (HEK293T) did not show a negative effect even at the highest concentration. However, the drug (cisplatin) response elaborated altered cellular morphology. MTT: 3-(4,5-dimethylthiazol-2yl)-2,5-biphenyl tetrazolium bromide; DMSO: dimethyl sulfoxide.

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