NLRP3 Susceptible Gene Polymorphisms in Patients with Primary Gouty Arthritis and Hyperuricemia

Table 3

The association between the risk of HUA and the genetic polymorphisms.

SNP	WT Ho/ Ht/ VR Ho			Codominant model					Dominant model			Recessive model			VR allele vs. WT allele
				VR Ho vs. WT Ho		Ht vs. WT Ho
	Control	GA	C_HWE	P	OR (95% CI)	P	OR (95% CI)	AIC	P	OR (95% CI)	AIC	P	OR (95% CI)	AIC	P	OR (95% CI)
rs10754558	132/266/109	113/189/75	0.29	0.27	0.80 (0.55-1.18)	0.24	0.83 (0.61-1.13)	1210.6	0.2	0.82 (0.61-1.11)	1208.6	0.56	0.91 (0.65-1.26)	1210	0.24	0.89 (0.73-1.08)
rs35829419	503/4/0	376/1/0	1			0.28	0.33 (0.04-3.00)	1209.1
rs3738448	325/165/17	242/109/26	0.57	0.024	2.05 (1.09-3.87)	0.42	0.89 (0.66-1.19)	1205.9	0.98	1.00 (0.75-1.32)	1210.3	0.016	2.14 (1.14-3.99)	1204.5	0.38	1.11 (0.88-1.39)
rs3806268	124/265/117	102/194/80	0.33	0.35	0.83 (0.56-1.22)	0.48	0.89 (0.65-1.23)	1208.5	0.38	0.87 (0.64-1.18)	1206.7	0.51	0.90 (0.65-1.24)	1207.1	0.34	0.91 (0.75-1.10)
rs7525979	325/165/17	357/199/158	0.57	0.037	1.96 (1.03-3.71)	0.36	0.87 (0.65-1.17)	1206.4	0.85	0.97 (0.74-1.29)	1210.3	0.024	2.05 (1.09-3.85)	1205.2	0.5	1.08 (0.86-1.36)

OR: odds ratio; VR: variant; WT: wild-type; Ht: heterozygote; VR Ho: variant homozygote; WT Ho: wide-type homozygote.