NLRP3 Susceptible Gene Polymorphisms in Patients with Primary Gouty Arthritis and Hyperuricemia

Table 4

Association of NLRP3 polymorphisms with clinical characteristics and risk of GA/HUA.

Category	rs3806268				rs3738448				rs7525979
	GA	Control	OR (95% CI)	value	HUA	Control	OR (95% CI)	value	HUA	Control	OR (95% CI)	value
Obesity
WT Ho (no)	72	109	1.00		162	277	1.00		163	277
Ht (no)	91	229	0.60 (0.41-0.88)	0.0097	85	143	1.02 (0.73-1.42)	0.92	85	143	1.01 (0.73-1.41)	0.95
VR Ho (no)	58	97	0.91 (0.58-1.41)	0.66	17	13	1.94 (0.94-3.98)	0.072	16	15	1.81 (0.87-3.76)	0.11
WT Ho (yes)	15	26	1.00		80	48	1.00		81	48	1.00
Ht (yes)	36	45	0.72 (0.33-1.56)	0.4	24	22	0.65 (0.33-1.29)	0.22	23	22	0.62 (0.31-1.23)	0.17
VR Ho (yes)	20	17	0.49 (0.20-1.21)	0.12	9	2	2.70 (0.56-13.02)	0.18	9	2	2.67 (0.55-12.86)	0.18
Smoking
WT Ho (no)	63	64	1.00		145	181	1.00		146	181	1.00
Ht (no)	90	154	0.59 (0.38-0.92)	0.018	63	100	0.79 (0.54-1.15)	0.22	62	100	0.77 (0.52-1.13)	0.18
VR Ho (no)	44	71	0.63 (0.38-1.05)	0.076	15	9	2.08 (0.88-4.89)	0.087	15	9	2.07 (0.88-4.86)	0.09
WT Ho (yes)	35	60	1.00		97	144	1.00		98	144	1.00
Ht (yes)	46	111	0.71 (0.41-1.22)	0.22	46	65	1.05 (0.67-1.66)	0.83	46	65	1.04 (0.66-1.64)	0.87
VR Ho (yes)	31	46	1.16 (0.62-2.14)	0.65	11	8	2.04 (0.79-5.26)	0.14	10	8	1.84 (0.70-4.82)	0.21
Hypertension
WT Ho (no)	31	78	1.00		100	188	1.00		100	189	1.00
Ht (no)	40	144	0.70 (0.41-1.20)	0.2	41	98	0.79 (0.51-1.22)	0.28	42	97	0.82 (0.53-1.27)	0.36
VR Ho (no)	21	77	0.69 (0.36-1.30)	0.24	9	13	1.30 (0.54-3.15)	0.56	8	13	1.16 (0.47-2.90)	0.75
WT Ho (yes)	67	46	1.00		142	137	1.00		144	136	1.00
Ht (yes)	96	121	0.54 (0.34-0.86)	0.0093	68	67	0.98 (0.65-1.48)	0.92	66	68	0.92 (0.61-1.38)	0.68
VR Ho (yes)	54	40	0.93 (0.53-1.61)	0.79	17	4	4.10 (1.35-12.49)	0.0056	17	4	4.01 (1.32-12.23)	0.0064
Drinking
WT ho (no)	60	69	1.00		104	190	1.00		105	189	1.00
Ht (no)	91	160	0.65 (0.42-1.01)	0.054	51	95	0.98 (0.65-1.49)	0.93	51	96	0.96 (0.63-1.45)	0.83
VR Ho (no)	44	61	0.83 (0.49-1.39)	0.48	10	5	3.65 (1.22-10.97)	0.016	9	5	3.24 (1.06-9.92)	0.034
WT Ho (yes)	38	55	1.00		138	135	1.00		139	136	1.00
Ht (yes)	45	105	0.75 (0.46-1.24)	0.28	58	70	0.81 (0.53-1.24)	0.33	57	69	0.81 (0.53-1.23)	0.32
VR Ho (yes)	31	56	0.80 (0.44-1.46)	0.47	16	12	1.30 (0.59-2.86)	0.51	16	12	1.30 (0.60-2.86)	0.5

OR (95% CI) and values were obtained from logistic regression analysis.