NLRP3 Susceptible Gene Polymorphisms in Patients with Primary Gouty Arthritis and Hyperuricemia

<table class="table-group" id="tab7"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">SNP</td><td class="align_center">Ref</td><td class="align_center">Alt</td><td class="align_center">SNP functional annotation</td><td class="align_center">3D interacting gene</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">rs3738448</td><td class="align_center">G</td><td class="align_center">T</td><td class="align_center">Promoter histone marks, enhancer histone marks, DNAse, proteins bound, motifs changed</td><td class="align_center">GALNT2, GCSAML, GCSAML-AS1, OR2B11, OR2C3, and OR2W5</td></tr><tr><td class="align_left">rs3806268</td><td class="align_center">G</td><td class="align_center">C</td><td class="align_center">Enhancer histone marks</td><td class="align_center">GALNT2, GCSAML, GCSAML-AS1, OR2B11, OR2C3, and OR2W5</td></tr><tr><td class="align_left">rs7525979</td><td class="align_center">C</td><td class="align_center">T</td><td class="align_center">Enhancer histone marks, motifs changed</td><td class="align_center">GALNT2, GCSAML, GCSAML-AS1, OR2B11, OR2C3, and OR2W5</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>SNP: single-nucleotide polymorphism; Ref: reference; Alt: alternation; eQTL: expression quantitative trait loci.<br/></div></td></tr></table>

<div>SNP functional annotation in HaploReg v4.1 and 3DSNP database.</div>

BioMed Research International

tab7

Table 7

Table 7: NLRP3 Susceptible Gene Polymorphisms in Patients with Primary Gouty Arthritis and Hyperuricemia 