Pioglitazone Mediates Cardiac Progenitor Formation through Increasing ROS Levels

<div>Percentage of fluorescence and gene expression in treatment with different concentrations of pioglitazone. (a) Illustrated protocol of mESCs to beating body differentiation. (b) Fluorescent imaging of beating bodies after differentiation of EBs treated in different concentrations of Pio, on day 7. (c) Percentages of fluorescence intensity in different concentrations of Pio, on day 7. (d) <i>Pparg</i> relative expression in stem cells, progenitors, and mature EBs in different concentrations of Pio, on day 7. (e) <i>Mef2c</i> relative expression in progenitors in different concentrations of Pio, on day 7. (f) <i>Nkx2,5</i> relative expression in progenitors in different concentrations of Pio, on day 7. 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Scale bar is 200 mm.</div>

BioMed Research International

fig1

Figure 1

Figure 1: Pioglitazone Mediates Cardiac Progenitor Formation through Increasing ROS Levels 