USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination

Figure 6

ARID2 expression is positively correlated with USP2 expression in lung cancer tissues. (a) WB assay on USP2 expression in paired lung cancer tumor tissues and normal tissues adjacent to tumor. (b, c) TCGA dataset analysis on the USP2 mRNA expression in paired lung squamous cell cancer/lung adenocarcinoma tissues and normal lung tissues ( indicates compared with group normal). (d–f) Immunohistochemistry assay to evaluate USP2 and ARID2 expression levels in paired samples of lung cancer tumor and normal tissues adjacent to tumor (d). Semiquantitative values of USP2 and ARID2 expression levels were calculated and statistically compared between cancer and normal tissues (e), and the correlation of USP2 and ARID2 expression levels were also examined (f) ( indicates compared with group tumor).

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