[Retracted] KDOAM-25 Overcomes Resistance to MEK Inhibitors by Targeting KDM5B in Uveal Melanoma

Figure 2

KDOAM-25 promotes cell apoptosis in MEK inhibitor-resistant UM cells. (a) CCK8 analysis of cell viability in 92.1-R cells treated with small compounds (5 μM) for 72 h. O: DMSO. (b) Colony number analysis in 92.1-P and 92.1-R cells treated with KDOAM-25 (5 μM) for 72 h. (c) CCK8 analysis of cell viability in 92.1-P and 92.1-R cells treated with KDOAM-25 (5 μM) for 72 h. (d) FACS analysis of cell apoptosis in OMM1-P and OMM1-R cells treated with KDOAM-25 (5 μM) for 24 h. (e) Quantitative analysis of percentage of cells in (d). ; one-way ANOVA in (a); two-way ANOVA in (b, c, e).

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