Anatomic Subsites and Prognosis of Gastric Signet Ring Cell Carcinoma: A SEER Population-Based 1 : 1 Propensity-Matched Study

Table 3

Impact of tumor localization on the CSS by univariate and multivariate survival analysis before PSM.

Characteristics		Univariate analysis		Multivariate analysis
		Log rank	value	HR	95% CI	value
Tumor localization		47.0	<0.001
	DGC			Reference
	OGC			1.33	1.28-1.37	<0.001
	PGC			1.18	1.10-1.23	<0.001
Age		45.0	<0.001
	18-49			Reference
	50-59			1.00	0.83-1.21	0.972
	60-69			1.02	0.85-1.23	0.816
	70-79			1.70	1.39-2.09	<0.001
	≥80			1.46	1.14-1.88	0.003
Race		13.9	0.003
	White			Reference
	Black			1.01	0.84-1.22	0.896
	API			0.86	0.72-1.03	0.093
	AI			1.07	0.53-2.19	0.843
Marital status		16.8	<0.001
	Divorced			Reference
	Married			0.98	0.81-1.19	0.843
	Widowed			1.01	0.78-1.31	0.954
	Single			1.04	0.83-1.30	0.751
Median household income		15.7	0.001
	Quartile 1			Reference
	Quartile 2			0.90	0.80-1.02	0.090
	Quartile 3			1.05	0.93-1.19	0.388
	Quartile 4			0.90	0.79-1.01	0.080
TNM stage		471.1	<0.001
	I			Reference
	II			1.88	1.46-2.42	<0.001
	III			3.77	2.98-4.75	<0.001
	IV			4.62	3.62-5.90	<0.001
Tumor size		247.9	<0.001
	≤2			Reference
	≤5			1.50	1.15-1.96	0.003
	>5 cm			2.15	1.64-2.81	<0.001
	Unknown			2.07	1.59-2.69	<0.001
Regional node examined		116.8	<0.001
	≤16			Reference
	>16			0.85	0.71-1.02	0.074
Bone metastasis		83.4	<0.001
	Yes			Reference
	No			0.86	0.64-1.15	0.299
Liver metastasis		94.0	<0.001
	Yes			Reference
	No			0.88	0.68-1.14	0.321
Lung metastasis		74.2	<0.001
	Yes			Reference
	No			0.87	0.63-1.19	0.374
Surgery		525.4	<0.001
	No			Reference
	Yes			0.34	0.28-0.40	<0.001
Radiation		22.2	<0.001
	No/unknown		Reference
	Yes			0.97	0.83-1.13	0.707
Chemotherapy		6.5	0.010
	No/unknown		Reference
	Yes			0.42	0.36-0.49	<0.001

CSS: cancer-specific survival; PSM: propensity score matching; HR: hazard ratio; CI: confidence interval.