The Therapeutic Effectiveness Using Fluorescence-Guided Surgery for MRONJ

Table 3

Summary of fluorescence manifestations and histological features in articles using fluorescence-guided surgery for MRONJ.

Research	Type of study	Surgical procedure	Fluorescence detection equipment	Intraoperative fluorescence		Histological changes
				Healthy bone	Necrotic bone
Pautke et al., [14]	N-RCT	Tetracycline fluorescence	VELscope	“Apple green” fluorescence	No or weak fluorescence	NA
Assaf et al., [13]	N-RCT	Tetracycline fluorescence	VELscope	Green fluorescence	No fluorescence	Nonfluorescent areas: Bone resorption destruction, inflammatory cell infiltration, granulation tissue hyperplasia
Otto et al., [12]	N-RCT	Tetracycline fluorescence	VELscope	Green fluorescence	No or weak fluorescence	NA
Ristow et al., [16]	RCTs	Tetracycline fluorescence	VELscope	Green fluorescence	No or weak fluorescence	Nonfluorescent areas are verified as necrotic bone
		Autofluorescence		Green fluorescence	No or weak fluorescence
Giudice et al., [15]	RCTs	Autofluorescence	VELscope	Green fluorescence	No fluorescence	Nonfluorescent areas are verified as necrotic bone
		Traditional technique	NA	NA
Otto et al. [11]	N-RCT	Autofluorescence	VELscope	Green fluorescence	No fluorescence	NA