[Retracted] Design and Characterization of Agarose/HPMC Buccal Films Bearing Ondansetron HCl In Vitro and In Vivo: Enhancement Using Iontophoretic and Chemical Approaches

Table 1

D-optimal experimental design based upon response surface methodology (RSM) of agarose/HPMC buccal film formulations.

Formulation code	Agarose; (X1)	HPMC; (X2)	Glycerol; (X3)
1	0.3 g (-1)	0.27 g (+1)	24% (+1)
2	0.3 g (-1)	0.27 g (+1)	12% (-1)
3	0.3 g (-1)	0.09 g (-1)	12% (-1)
4	0.3 g (-1)	0.18 g (0)	18% (0)
5	0.45 g (0)	0.27 g (+1)	18% (0)
6	0.45 g (0)	0.18 g (0)	12% (-1)
7	0.6 g (+1)	0.27 g (+1)	12% (-1)
8	0.6 g (+1)	0.27 g (+1)	24% (+1)
9	0.6 g (+1)	0.09 g (-1)	18% (0)
10	0.45 g (0)	0.09 g (-1)	24% (+1)
11	0.525 g (0.5)	0.18 g (0)	21% (0.5)
12	0.6 g (+1)	0.09 g (-1)	12% (-1)
13	0.3 g (-1)	0.09 g (-1)	24% (+1)
14	0.6 g (+1)	0.09 g (-1)	24% (+1)
15	0.45 g (0)	0.09 g (-1)	12% (-1)
16	0.3 g (-1)	0.27 g (+1)	24% (+1)
17	0.6 g (+1)	0.27 g (+1)	12% (-1)
18	0.3 g (-1)	0.27 g (+1)	12% (-1)
19	0.6 g (+1)	0.27 g (+1)	24% (+1)
20	0.45 g (0)	0.27 g (+1)	18% (0)

The drug concentration per patch of 1 cm² is .