Comparison of Different First-Line Systemic Therapies in Advanced Biliary Tract Cancer Based on Updated Random Controlled Trials: A Systematic Review and Network Meta-Analysis

Table 2

League table of network meta-analysis for overall survival.

XELOX	0.01 (0.00,41.97)	0.33 (0.00,241.23)	0.00 (0.00,0.95)	0.04 (0.00,241.27)	0.37 (0.00,146.43)	0.61 (0.00,1354.88)	0.82 (0.00,321.73)	0.20 (0.00,203.30)	0.82 (0.00,165.96)	0.03 (0.00,14.67)	1.11 (0.00,533.95)	1.49 (0.00,530.77)	3.67 (0.01,2527.53)	0.41 (0.00,117.26)	0.09 (0.00,35.58)	0.01 (0.00,4.36)	0.05 (0.00,35.98)	0.01 (0.00,5.20)
153.84 (0.02,993240.63)	Vandetanib	51.26 (0.03,92246.31)	0.36 (0.00,246.30)	6.48 (0.06,682.50)	57.51 (0.08,39854.70)	93.31 (0.01,715102.88)	125.95 (0.07,227252.61)	31.06 (0.01,120941.94)	125.95 (0.12,135655.52)	5.14 (0.00,5983.74)	170.21 (0.13,215049.52)	229.74 (0.24,223152.33)	565.07 (0.33,972537.06)	62.61 (0.08,50881.98)	13.83 (0.02,8480.31)	0.94 (0.00,2748.49)	7.67 (0.00,13762.77)	0.85 (0.00,3124.77)
3.00 (0.00,2172.54)	0.02 (0.00,35.10)	S1Cis	0.01 (0.00,0.35)	0.13 (0.00,197.64)	1.12 (0.02,52.99)	1.82 (0.00,1653.10)	2.46 (0.02,285.55)	0.61 (0.00,219.90)	2.46 (0.05,120.36)	0.10 (0.00,5.63)	3.32 (0.05,215.00)	4.48 (0.11,181.68)	11.02 (0.10,1188.14)	1.22 (0.04,35.14)	0.27 (0.01,12.95)	0.02 (0.00,4.42)	0.15 (0.00,17.23)	0.02 (0.00,5.55)
432.41 (1.05,177966.17)	2.81 (0.00,1945.93)	144.09 (2.83,7345.30)	S1	18.22 (0.03,10727.31)	161.64 (56.25,464.50)	262.27 (0.50,138215.56)	354.03 (6.91,18140.78)	87.30 (0.46,16733.89)	354.03 (20.83,6016.86)	14.45 (0.71,295.87)	478.42 (19.38,11809.25)	645.76 (49.54,8417.50)	1588.30 (33.94,74324.37)	175.99 (22.83,1356.60)	38.89 (11.08,136.52)	2.64 (0.02,319.01)	21.55 (0.42,1093.41)	2.39 (0.01,418.21)
23.73 (0.00,135855.92)	0.15 (0.00,16.24)	7.91 (0.01,12357.14)	0.05 (0.00,32.31)	Gem+Vandetanib	8.87 (0.02,5227.58)	14.39 (0.00,98040.73)	19.43 (0.01,30443.90)	4.79 (0.00,16419.48)	19.43 (0.02,17980.72)	0.79 (0.00,794.48)	26.25 (0.02,28602.97)	35.44 (0.04,29509.32)	87.16 (0.06,130167.20)	9.66 (0.01,6700.38)	2.13 (0.00,1108.80)	0.14 (0.00,371.42)	1.18 (0.00,1843.55)	0.13 (0.00,423.85)
2.68 (0.01,1047.89)	0.02 (0.00,12.05)	0.89 (0.02,42.11)	0.01 (0.00,0.02)	0.11 (0.00,66.44)	GemS1	1.62 (0.00,815.43)	2.19 (0.05,104.01)	0.54 (0.00,97.82)	2.19 (0.14,33.46)	0.09 (0.00,1.66)	2.96 (0.13,66.51)	4.00 (0.34,46.27)	9.83 (0.23,425.34)	1.09 (0.16,7.22)	0.24 (0.07,0.85)	0.02 (0.00,1.85)	0.13 (0.00,6.27)	0.01 (0.00,2.44)
1.65 (0.00,3682.94)	0.01 (0.00,82.14)	0.55 (0.00,498.95)	0.00 (0.00,2.01)	0.07 (0.00,473.29)	0.62 (0.00,309.74)	GemOxa+Panitumumab	1.35 (0.00,680.47)	0.33 (0.00,416.10)	1.35 (0.01,361.54)	0.06 (0.00,30.89)	1.82 (0.00,1120.36)	2.46 (0.01,1127.17)	6.06 (0.01,5236.74)	0.67 (0.00,251.27)	0.15 (0.00,75.24)	0.01 (0.00,9.02)	0.08 (0.00,74.42)	0.01 (0.00,10.66)
1.22 (0.00,479.97)	0.01 (0.00,14.33)	0.41 (0.00,47.30)	0.00 (0.00,0.14)	0.05 (0.00,80.66)	0.46 (0.01,21.68)	0.74 (0.00,373.45)	GemOxa+Erlotinib	0.25 (0.00,44.83)	1.00 (0.07,15.38)	0.04 (0.00,2.31)	1.35 (0.02,87.98)	1.82 (0.04,74.39)	4.49 (0.04,485.90)	0.50 (0.02,14.40)	0.11 (0.00,5.30)	0.01 (0.00,0.85)	0.06 (0.00,7.05)	0.01 (0.00,1.12)
4.95 (0.00,4987.37)	0.03 (0.00,125.37)	1.65 (0.00,599.01)	0.01 (0.00,2.20)	0.21 (0.00,715.36)	1.85 (0.01,335.33)	3.00 (0.00,3755.34)	4.06 (0.02,737.14)	GemOxa+Cetuximab	4.06 (0.05,339.33)	0.17 (0.00,34.15)	5.48 (0.02,1259.63)	7.40 (0.05,1197.72)	18.19 (0.05,6238.61)	2.02 (0.02,255.77)	0.45 (0.00,81.61)	0.03 (0.00,10.81)	0.25 (0.00,89.31)	0.03 (0.00,13.29)
1.22 (0.01,247.58)	0.01 (0.00,8.55)	0.41 (0.01,19.94)	0.00 (0.00,0.05)	0.05 (0.00,47.64)	0.46 (0.03,6.97)	0.74 (0.00,198.42)	1.00 (0.07,15.38)	0.25 (0.00,20.63)	GemOxa	0.04 (0.00,0.79)	1.35 (0.06,31.76)	1.82 (0.15,22.36)	4.49 (0.10,201.55)	0.50 (0.07,3.54)	0.11 (0.01,1.72)	0.01 (0.00,0.36)	0.06 (0.00,2.97)	0.01 (0.00,0.51)
29.93 (0.07,13137.47)	0.19 (0.00,226.47)	9.97 (0.18,560.41)	0.07 (0.00,1.42)	1.26 (0.00,1263.82)	11.19 (0.60,207.33)	18.15 (0.03,10177.44)	24.50 (0.43,1384.65)	6.04 (0.03,1246.77)	24.50 (1.26,476.38)	GemCis+Ramucirumab	33.11 (3.43,320.12)	44.70 (2.96,674.73)	109.93 (2.13,5682.62)	12.18 (1.32,112.61)	2.69 (0.14,50.92)	0.18 (0.00,23.94)	1.49 (0.03,83.43)	0.17 (0.00,31.21)
0.90 (0.00,436.18)	0.01 (0.00,7.42)	0.30 (0.00,19.50)	0.00 (0.00,0.05)	0.04 (0.00,41.49)	0.34 (0.02,7.59)	0.55 (0.00,336.68)	0.74 (0.01,48.17)	0.18 (0.00,41.94)	0.74 (0.03,17.39)	0.03 (0.00,0.29)	GemCis+Merestinib	1.35 (0.07,25.04)	3.32 (0.06,198.32)	0.37 (0.03,4.36)	0.08 (0.00,1.86)	0.01 (0.00,0.81)	0.05 (0.00,2.90)	0.00 (0.00,1.05)
0.67 (0.00,237.99)	0.00 (0.00,4.23)	0.22 (0.01,9.05)	0.00 (0.00,0.02)	0.03 (0.00,23.50)	0.25 (0.02,2.90)	0.41 (0.00,185.93)	0.55 (0.01,22.36)	0.14 (0.00,21.89)	0.55 (0.04,6.72)	0.02 (0.00,0.34)	0.74 (0.04,13.75)	GemCis+Durvalumab	2.46 (0.07,91.03)	0.27 (0.06,1.29)	0.06 (0.01,0.71)	0.00 (0.00,0.41)	0.03 (0.00,1.35)	0.00 (0.00,0.55)
0.27 (0.00,187.33)	0.00 (0.00,3.05)	0.09 (0.00,9.78)	0.00 (0.00,0.03)	0.01 (0.00,17.13)	0.10 (0.00,4.41)	0.17 (0.00,142.79)	0.22 (0.00,24.14)	0.05 (0.00,18.85)	0.22 (0.00,10.01)	0.01 (0.00,0.47)	0.30 (0.01,17.99)	0.41 (0.01,15.05)	GemCis+Cediranib	0.11 (0.00,2.88)	0.02 (0.00,1.08)	0.00 (0.00,0.38)	0.01 (0.00,1.46)	0.00 (0.00,0.48)
2.46 (0.01,707.90)	0.02 (0.00,12.98)	0.82 (0.03,23.55)	0.01 (0.00,0.04)	0.10 (0.00,71.84)	0.92 (0.14,6.09)	1.49 (0.00,558.03)	2.01 (0.07,58.26)	0.50 (0.00,62.94)	2.01 (0.28,14.34)	0.08 (0.01,0.76)	2.72 (0.23,32.19)	3.67 (0.77,17.40)	9.03 (0.35,234.78)	GemCis	0.22 (0.03,1.51)	0.01 (0.00,1.15)	0.12 (0.00,3.50)	0.01 (0.00,1.56)
11.12 (0.03,4399.84)	0.07 (0.00,44.31)	3.71 (0.08,177.81)	0.03 (0.01,0.09)	0.47 (0.00,243.48)	4.16 (1.18,14.67)	6.74 (0.01,3422.44)	9.10 (0.19,439.12)	2.25 (0.01,411.33)	9.10 (0.58,142.17)	0.37 (0.02,7.03)	12.30 (0.54,281.90)	16.61 (1.40,197.13)	40.84 (0.93,1796.71)	4.53 (0.66,30.97)	Gem	0.07 (0.00,7.81)	0.55 (0.01,26.47)	0.06 (0.00,10.27)
163.91 (0.23,117113.23)	1.07 (0.00,3120.00)	54.62 (0.23,13199.07)	0.38 (0.00,45.84)	6.91 (0.00,17720.67)	61.27 (0.54,6962.16)	99.41 (0.11,89151.14)	134.20 (1.18,15315.42)	33.09 (0.09,11835.69)	134.20 (2.80,6429.06)	5.48 (0.04,717.97)	181.35 (1.23,26745.98)	244.78 (2.44,24591.10)	602.05 (2.65,136883.86)	66.71 (0.87,5112.90)	14.74 (0.13,1696.22)	FUFA	8.17 (0.03,1967.45)	0.91 (0.02,39.51)
20.06 (0.03,14484.18)	0.13 (0.00,234.11)	6.69 (0.06,770.32)	0.05 (0.00,2.35)	0.85 (0.00,1318.04)	7.50 (0.16,352.59)	12.17 (0.01,11022.15)	16.43 (0.14,1901.68)	4.05 (0.01,1465.57)	16.43 (0.34,800.83)	0.67 (0.01,37.50)	22.20 (0.34,1431.03)	29.96 (0.74,1208.56)	73.70 (0.69,7912.07)	8.17 (0.29,233.62)	1.80 (0.04,86.17)	0.12 (0.00,29.48)	FOLFIRINOX	0.11 (0.00,37.00)
181.03 (0.19,170284.88)	1.18 (0.00,4326.85)	60.32 (0.18,20202.81)	0.42 (0.00,73.30)	7.63 (0.00,24666.99)	67.67 (0.41,11183.92)	109.80 (0.09,128487.02)	148.21 (0.89,24602.12)	36.55 (0.08,17748.36)	148.21 (1.97,11142.27)	6.05 (0.03,1141.76)	200.29 (0.95,42193.50)	270.34 (1.83,39875.12)	664.94 (2.10,210244.08)	73.68 (0.64,8474.71)	16.28 (0.10,2722.17)	1.10 (0.03,48.19)	9.02 (0.03,3012.00)	BSC

GemCis: gemcitabine plus cisplatin; GemOxa: gemcitabine plus oxaliplatin; GemS1: gemcitabine plus S-1; S1Cis: S1 plus cisplatin; XELOX: capecitabine plus oxaliplatin; BSC: best supportive care; FUFA: fluorouracil+folinic; FOLFIRINOX: oxaliplatin plus irinotecan plus infusional fluorouracil.