Comparison of Different First-Line Systemic Therapies in Advanced Biliary Tract Cancer Based on Updated Random Controlled Trials: A Systematic Review and Network Meta-Analysis

Table 4

League table of network meta-analysis for progression-free survival.

XELOX	0.00 (0.00,0.27)	0.17 (0.00,10.22)	0.02 (0.00,0.85)	0.00 (0.00,0.41)	0.37 (0.01,15.83)	1.49 (0.04,57.99)	3.00 (0.12,77.38)	1.11 (0.04,27.26)	0.61 (0.04,8.43)	0.20 (0.01,6.49)	0.33 (0.01,10.47)	1.00 (0.03,36.18)	0.41 (0.01,18.64)	0.22 (0.01,6.97)	0.01 (0.00,0.50)	0.00 (0.00,0.11)	0.07 (0.00,3.66)	0.00 (0.00,0.06)
304.78 (3.77,24666.12)	Vandetanib	50.51 (1.44,1769.22)	4.70 (0.17,132.63)	1.35 (0.10,17.38)	111.69 (5.17,2413.56)	454.67 (5.92,34913.49)	915.60 (16.77,49995.71)	336.83 (6.39,17758.75)	184.86 (5.48,6231.83)	61.70 (3.86,986.06)	101.72 (6.55,1580.73)	305.59 (16.52,5653.47)	124.24 (5.04,3060.64)	68.19 (4.42,1050.81)	4.18 (0.33,52.49)	1.25 (0.02,71.19)	20.54 (0.68,621.06)	0.62 (0.01,35.57)
6.03 (0.10,372.13)	0.02 (0.00,0.69)	S1Cis	0.09 (0.00,2.00)	0.03 (0.00,1.10)	2.21 (0.14,34.33)	9.00 (0.15,524.88)	18.13 (0.45,732.86)	6.67 (0.17,259.57)	3.66 (0.15,87.30)	1.22 (0.12,12.38)	2.01 (0.21,19.74)	6.05 (0.50,72.93)	2.46 (0.15,41.25)	1.35 (0.14,13.10)	0.08 (0.01,1.01)	0.02 (0.00,1.05)	0.41 (0.02,8.59)	0.01 (0.00,0.52)
64.85 (1.18,3567.02)	0.21 (0.01,6.00)	10.75 (0.50,230.59)	S1	0.29 (0.01,9.62)	23.77 (5.24,107.76)	96.74 (1.86,5023.05)	194.82 (5.48,6930.57)	71.67 (2.10,2451.33)	39.33 (1.92,807.39)	13.13 (1.60,107.85)	21.64 (2.73,171.34)	65.02 (6.55,645.40)	26.44 (1.87,374.05)	14.51 (1.85,113.59)	0.89 (0.10,7.86)	0.27 (0.01,9.92)	4.37 (0.24,78.96)	0.13 (0.00,4.96)
225.81 (2.45,20850.08)	0.74 (0.06,9.54)	37.42 (0.91,1540.78)	3.48 (0.10,116.66)	Gem+Vandetanib	82.75 (3.18,2153.07)	336.86 (3.84,29557.82)	678.36 (10.75,42794.08)	249.55 (4.09,15219.42)	136.96 (3.45,5436.28)	45.71 (2.33,896.40)	75.36 (3.94,1439.80)	226.41 (10.07,5090.31)	92.05 (3.13,2710.76)	50.52 (2.66,957.68)	3.10 (0.20,48.58)	0.92 (0.01,60.84)	15.22 (0.43,544.47)	0.46 (0.01,30.39)
2.73 (0.06,117.88)	0.01 (0.00,0.19)	0.45 (0.03,7.02)	0.04 (0.01,0.19)	0.01 (0.00,0.31)	GemS1	4.07 (0.10,165.37)	8.20 (0.30,221.87)	3.02 (0.12,78.22)	1.66 (0.11,24.46)	0.55 (0.11,2.73)	0.91 (0.19,4.29)	2.74 (0.43,17.25)	1.11 (0.12,10.74)	0.61 (0.13,2.83)	0.04 (0.01,0.21)	0.01 (0.00,0.32)	0.18 (0.01,2.35)	0.01 (0.00,0.16)
0.67 (0.02,26.06)	0.00 (0.00,0.17)	0.11 (0.00,6.48)	0.01 (0.00,0.54)	0.00 (0.00,0.26)	0.25 (0.01,9.98)	GemOxa+Panitumumab	2.01 (0.08,48.29)	0.74 (0.03,17.00)	0.41 (0.03,5.17)	0.14 (0.00,4.07)	0.22 (0.01,6.56)	0.67 (0.02,22.73)	0.27 (0.01,11.76)	0.15 (0.01,4.37)	0.01 (0.00,0.31)	0.00 (0.00,0.07)	0.05 (0.00,2.32)	0.00 (0.00,0.03)
0.33 (0.01,8.57)	0.00 (0.00,0.06)	0.06 (0.00,2.23)	0.01 (0.00,0.18)	0.00 (0.00,0.09)	0.12 (0.00,3.30)	0.50 (0.02,11.91)	GemOxa+Erlotinib	0.37 (0.03,5.16)	0.20 (0.03,1.36)	0.07 (0.00,1.29)	0.11 (0.01,2.07)	0.33 (0.02,7.34)	0.14 (0.00,3.92)	0.07 (0.00,1.38)	0.00 (0.00,0.10)	0.00 (0.00,0.02)	0.02 (0.00,0.79)	0.00 (0.00,0.01)
0.90 (0.04,22.32)	0.00 (0.00,0.16)	0.15 (0.00,5.84)	0.01 (0.00,0.48)	0.00 (0.00,0.24)	0.33 (0.01,8.60)	1.35 (0.06,30.97)	2.72 (0.19,38.11)	GemOxa+Cetuximab	0.55 (0.09,3.42)	0.18 (0.01,3.35)	0.30 (0.02,5.37)	0.91 (0.04,19.07)	0.37 (0.01,10.21)	0.20 (0.01,3.57)	0.01 (0.00,0.26)	0.00 (0.00,0.06)	0.06 (0.00,2.06)	0.00 (0.00,0.03)
1.65 (0.12,22.92)	0.01 (0.00,0.18)	0.27 (0.01,6.52)	0.03 (0.00,0.52)	0.01 (0.00,0.29)	0.60 (0.04,8.93)	2.46 (0.19,31.30)	4.95 (0.74,33.25)	1.82 (0.29,11.35)	GemOxa	0.33 (0.03,3.19)	0.55 (0.06,5.08)	1.65 (0.14,18.87)	0.67 (0.04,10.74)	0.37 (0.04,3.37)	0.02 (0.00,0.26)	0.01 (0.00,0.05)	0.11 (0.01,2.25)	0.00 (0.00,0.02)
4.94 (0.15,158.41)	0.02 (0.00,0.26)	0.82 (0.08,8.30)	0.08 (0.01,0.63)	0.02 (0.00,0.43)	1.81 (0.37,8.96)	7.37 (0.25,221.04)	14.84 (0.77,284.52)	5.46 (0.30,99.80)	3.00 (0.31,28.65)	GemCis+Ramucirumab	1.65 (1.06,2.58)	4.95 (1.63,15.04)	2.01 (0.36,11.34)	1.11 (0.71,1.73)	0.07 (0.02,0.21)	0.02 (0.00,0.41)	0.33 (0.04,2.67)	0.01 (0.00,0.21)
3.00 (0.10,93.95)	0.01 (0.00,0.15)	0.50 (0.05,4.87)	0.05 (0.01,0.37)	0.01 (0.00,0.25)	1.10 (0.23,5.17)	4.47 (0.15,131.03)	9.00 (0.48,168.08)	3.31 (0.19,58.93)	1.82 (0.20,16.78)	0.61 (0.39,0.95)	GemCis+Merestinib	3.00 (1.06,8.49)	1.22 (0.23,6.57)	0.67 (0.54,0.83)	0.04 (0.01,0.12)	0.01 (0.00,0.24)	0.20 (0.03,1.56)	0.01 (0.00,0.12)
1.00 (0.03,35.99)	0.00 (0.00,0.06)	0.17 (0.01,1.99)	0.02 (0.00,0.15)	0.00 (0.00,0.10)	0.37 (0.06,2.30)	1.49 (0.04,50.33)	3.00 (0.14,65.92)	1.10 (0.05,23.17)	0.60 (0.05,6.91)	0.20 (0.07,0.61)	0.33 (0.12,0.94)	GemCis+Durvalumab	0.41 (0.06,2.87)	0.22 (0.08,0.62)	0.01 (0.00,0.06)	0.00 (0.00,0.10)	0.07 (0.01,0.65)	0.00 (0.00,0.05)
2.45 (0.05,112.14)	0.01 (0.00,0.20)	0.41 (0.02,6.82)	0.04 (0.00,0.54)	0.01 (0.00,0.32)	0.90 (0.09,8.68)	3.66 (0.09,157.47)	7.37 (0.26,212.74)	2.71 (0.10,75.06)	1.49 (0.09,23.79)	0.50 (0.09,2.80)	0.82 (0.15,4.40)	2.46 (0.35,17.36)	GemCis+Cediranib	0.55 (0.10,2.91)	0.03 (0.00,0.24)	0.01 (0.00,0.31)	0.17 (0.01,2.30)	0.00 (0.00,0.15)
4.47 (0.14,139.23)	0.01 (0.00,0.23)	0.74 (0.08,7.19)	0.07 (0.01,0.54)	0.02 (0.00,0.38)	1.64 (0.35,7.60)	6.67 (0.23,194.16)	13.43 (0.72,248.79)	4.94 (0.28,87.22)	2.71 (0.30,24.78)	0.90 (0.58,1.42)	1.49 (1.20,1.85)	4.48 (1.62,12.38)	1.82 (0.34,9.67)	GemCis	0.06 (0.02,0.17)	0.02 (0.00,0.36)	0.30 (0.04,2.31)	0.01 (0.00,0.18)
72.95 (2.01,2647.34)	0.24 (0.02,3.01)	12.09 (0.99,147.02)	1.12 (0.13,9.95)	0.32 (0.02,5.07)	26.74 (4.68,152.82)	108.83 (3.20,3702.71)	219.16 (9.90,4853.96)	80.63 (3.81,1706.41)	44.25 (3.84,509.40)	14.77 (4.77,45.70)	24.35 (8.44,70.20)	73.15 (17.12,312.48)	29.74 (4.17,212.21)	16.32 (5.79,46.05)	Gem	0.30 (0.01,7.00)	4.92 (0.50,48.26)	0.15 (0.01,3.51)
244.65 (8.98,6664.04)	0.80 (0.01,45.87)	40.55 (0.95,1721.90)	3.77 (0.10,141.21)	1.08 (0.02,71.41)	89.66 (3.14,2563.92)	364.97 (14.37,9267.57)	734.97 (46.51,11612.93)	270.38 (18.01,4059.50)	148.39 (20.12,1094.31)	49.52 (2.43,1009.45)	81.65 (4.11,1621.93)	245.30 (10.51,5722.68)	99.73 (3.27,3038.64)	54.73 (2.78,1078.93)	3.35 (0.14,78.74)	FUFA	16.49 (0.45,609.21)	0.50 (0.19,1.30)
14.84 (0.27,806.92)	0.05 (0.00,1.47)	2.46 (0.12,51.97)	0.23 (0.01,4.14)	0.07 (0.00,2.35)	5.44 (0.42,69.61)	22.14 (0.43,1136.10)	44.58 (1.27,1565.59)	16.40 (0.49,553.67)	9.00 (0.45,181.95)	3.00 (0.37,24.14)	4.95 (0.64,38.34)	14.88 (1.53,144.72)	6.05 (0.44,84.11)	3.32 (0.43,25.41)	0.20 (0.02,2.00)	0.06 (0.00,2.24)	FOLFIRINOX	0.03 (0.00,1.12)
492.65 (17.95,13522.75)	1.62 (0.03,92.95)	81.65 (1.91,3490.87)	7.60 (0.20,286.34)	2.18 (0.03,144.68)	180.55 (6.27,5202.06)	734.95 (28.72,18809.00)	1480.00 (92.81,23600.70)	544.46 (35.93,8251.45)	298.81 (40.01,2231.70)	99.73 (4.85,2049.86)	164.43 (8.21,3293.84)	493.96 (21.00,11616.69)	200.83 (6.54,6164.38)	110.22 (5.54,2191.16)	6.75 (0.29,159.84)	2.01 (0.77,5.29)	33.20 (0.89,1235.40)	BSC

GemCis: gemcitabine plus cisplatin; GemOxa: gemcitabine plus oxaliplatin; GemS1: gemcitabine plus S-1; S1Cis: S1 plus cisplatin; XELOX: capecitabine plus oxaliplatin; BSC: best supportive care; FUFA: fluorouracil+folinic; FOLFIRINOX: oxaliplatin plus irinotecan plus infusional fluorouracil.