Antioxidant Mechanism of Renal and Hepatic Failure Prevention Related to Paracetamol Overdose by the Aqueous Extract of Amblygonocarpus andongensis Stem Bark

Figure 7

Microphotographs of rat livers (×200, hematoxylin-eosin stain). (a) Normal control. (b) Negative control. (c) Positive control treated with 0.9% normal saline. (d) Positive control treated with N-acetylcysteine. (e–g) Groups treated with aqueous extract of A. andongensis stem bark at doses of 125, 250, and 500 mg/kg, respectively. (h) Satellite control. (i) Satellite treated with aqueous extract of A. andongensis stem bark at the dose of 500 mg/kg. Hp: hepatic portal vein; He: hepatocyte; Ha: hepatic artery; Bd: bile duct; Sc: sinusoidal capillary; LI: leukocyte infiltration; DCh: dilatation and congestion of hepatic portal vein; Dh: dilatation of Hepatic portal vein.

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