Antioxidant Mechanism of Renal and Hepatic Failure Prevention Related to Paracetamol Overdose by the Aqueous Extract of Amblygonocarpus andongensis Stem Bark

Table 3

Effect of AEAASB on some parameters related to renal function.

	Urine output (ml/min ×10^-2)	Urinary creatinine (mg/dl)	Urinary pH	Urinary osmolarity	Urinary protein (mg/dl)	Creatinine serum (mg/dl)	Urea serum (mg/dl)	Renal clearance (ml/min)
Normal control
Negative control		^♦♦			^♦♦♦	^♦♦♦	^♦♦♦	^♦♦♦
Positive control-PS
Positive control-NAC
AEAASB 125
AEAASB 250
AEAASB 500
Satellite control
Satellite AEAASB 500							^●●●	^●●

Values are expressed as ; positive control-PS: treated with 0.9% normal saline; positive control-NAC: treated with N-acetylcysteine; AEAASB 125, AEAASB 250, AEAASB 500: groups treated with aqueous extract of A. andongensis stem bark at doses of 125, 250, and 500 mg/kg, respectively; Satellite AEAASB 500: treated with aqueous extract of A. andongensis stem bark at the dose of 500 mg/kg. ^♦♦, ^♦♦♦ significant difference compared to the normal control, , , significant difference compared to the negative control, ^●●, ^●●● significant difference compared to the satellite control.