Antioxidant Mechanism of Renal and Hepatic Failure Prevention Related to Paracetamol Overdose by the Aqueous Extract of Amblygonocarpus andongensis Stem Bark

Table 4

Effect of AEAASB on some markers of liver function.

	ASAT (UI/ml)	ALAT (UI/ml)	Alkaline phosphatase (UI/ml)	Direct bilirubin (μmol/l)	Total bilirubin (μmol/l)
Normal control
Negative control	^♦♦♦	^♦♦♦	^♦♦♦	^♦♦♦	^♦♦♦
Positive control-PS
Positive control-NAC
AEAASB 125
AEAASB 250
AEAASB 500
Satellite control
Satellite AEAASB 500		^●●●	^●●	^●●

Values are expressed as ; positive control-PS: treated with 0.9% normal saline; positive control-NAC: treated with N-acetylcysteine; AEAASB 125, AEAASB 250, AEAASB 500: groups treated with aqueous extract of A. andongensis stem bark at doses of 125, 250, and 500 mg/kg, respectively; satellite AEAASB 500: treated with aqueous extract of A. andongensis stem bark at the dose of 500 mg/kg. ^♦♦♦ significant difference compared to the normal control, , , significant difference compared to the negative control, ^●●, ^●●● significant difference compared to the satellite control.