Antioxidant Mechanism of Renal and Hepatic Failure Prevention Related to Paracetamol Overdose by the Aqueous Extract of Amblygonocarpus andongensis Stem Bark

Table 5

Effect of AEAASB on some parameters of oxidative stress, total protein, and NO levels in kidney and liver tissues.

	Total protein	MDA (mmol/mg of protein)	SOD (U/mg of protein)	CAT (μmol/min/mg of protein)	GSH (mmol/mg of protein)	NO (mmol/mg of protein)
Kidney tissue
Normal control
Negative control		^♦♦♦	^♦♦	^♦♦	^♦♦	^♦♦♦
Positive control-PS
Positive control-NAC
AEAASB 125
AEAASB 250
AEAASB 500
Satellite control
Satellite AEAASB 500		^●	^●		^●
Liver tissue
Normal control
Negative control		^♦♦	^♦♦	^♦	^♦♦♦	^♦♦♦
Positive control-PS
Positive control-NAC
AEAASB 125
AEAASB 250
AEAASB 500
Satellite control
Satellite AEAASB 500				^●●●	^●●●

Values are expressed as ; positive control-PS: treated with 0.9% normal saline; positive control-NAC: treated with N-acetylcysteine; AEAASB 125, AEAASB 250, AEAASB 500: groups treated with aqueous extract of A. andongensis stem bark at doses of 125, 250, and 500 mg/kg, respectively; satellite AEAASB 500: treated with aqueous extract of A. andongensis stem bark at the dose of 500 mg/kg. ^♦, ^♦♦, ^♦♦♦ significant difference compared to the normal control, , , significant difference compared to the negative control, ^●, ^●●● significant difference compared to the satellite control.